Effects of Low Intensity, High Intensity Eccentric Resistance Training Associated With Blood Flow Restriction

Exercise Clinical Trial

— oclusion  

Official title:

Effects of Low Intensity, High Intensity Eccentric Resistance Training Associated With Blood Flow Restriction: a Randomized Controlled Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03601104
• Other study ID #: 680075683140
• Status: Completed
• Phase: N/A
• Start date: March 12, 2019
• Est. completion date: December 31, 2020

Study information

• Verified date: March 2021
• Source: Paulista University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Introduction: studies on resistance training of low intensity associated with blood flow restriction in recent years, although there are still gaps that can be explored in relation to their physiological phenomena when associated with eccentric training. In this way, from there the exploration becomes relevant the investigation of eccentric training associated to an RFS. Objective: To analyze and compare the effects of a high intensity and low intensity intensive resistance training associated with an RFS (TREAI-RFS and TREBI-RFS) with a high intensity eccentric resistance training without RFS (TREAI) in knee extensors. Method: The study will consist of 45 male participants, allocated from a stratified randomization into three groups: TREAI (n = 15), TREAI-RFS (n = 15) and TREBI-RFS (n = 15). Participants underwent a training program with a minimum of 40% without RFS, 80% with RFS and 40% with CVS of CVIM, 3 times a week, and the outcomes of muscle strength, muscle structure, power test and Endothelial growth will be assessed one week before, the fourth week and one week after the end of the training program. In addition, clinical markers of perception and recovery effort are investigated before and after a session. The graph used is descriptive and descriptive, as it is used as a model of analysis of variance for the analysis of replications without a two-factor scheme, which provides detailed information on how the measures are repeated, neither. A whole statistical analysis can reach the level of significance of 5%.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 61
• Est. completion date: December 31, 2020
• Est. primary completion date: May 12, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 35 Years

Eligibility

Inclusion Criteria:

• male sex;

• healthy;

• aged between 18 and 35 years

Exclusion Criteria:

• smokers;

• alcoholics;

• use drugs that influenced cardiac autonomic activity;

• cardiovascular, metabolic or endocrine diseases.

Related Conditions & MeSH terms

• Exercise

Intervention

Other:
• High intensity eccentric training
High intensity eccentric training group with 80% of isometric peak torque.
• High intensity eccentric training with BFR
Eccentric high intensity training group with 80% of isometric peak torque associated with blood flow restriction (40% of absolute occlusion pressure).
• Low intensity eccentric training with BFR
Low intensity eccentric training group with 40% of isometric peak torque associated with blood flow restriction (40% of absolute occlusion pressure).
• Low intensity eccentric training
Low intensity eccentric training group with 40% of isometric peak torque

Locations

Country	Name	City	State
Brazil	Franciele Marques Vanderlei	Presidente Prudente	SP

Sponsors (1)

Lead Sponsor	Collaborator
Paulista University

Country where clinical trial is conducted

Brazil, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in muscle strength torque peaks at dinamometer isokinetic	The isometric, eccentric and concentric torque peaks will be measured with an isokinetic dynamometer in order to evaluate the adaptations of knee extensor force to eccentric training.	baseline, fourth week and one week after sixth week
Primary	Change in muscular structure with ultrasonography	Ultrasonographic imaging of the dominant lower limb will be captured to determine muscle thickness of the vastus lateralis (VL) and rectus femoris (RF) muscles.	baseline, fourth week and one week after sixth week.
Primary	Change in Vascular Endothelial Growth Factor (VEGF)	For the analysis of the concentration of endothelial growth factor (VEGF) will be collected 10 ml of blood sample. The plasma of this sample will be stored at -80 ° C for further analysis.	baseline, fourth week and one week after sixth week.
Primary	Change in muscle power test	The strength and muscle power tests will be performed on a vertical squat with a guided bar.	baseline, fourth week and one week after sixth week.
Secondary	Pain threshold	To assess the pain threshold, the pressure algometer will be applied at five specific locations on the quadriceps.	Assessed at baseline, 4th week, and 6th week.
Secondary	Analog Visual Scale	The subjective evaluation of pain will be obtained through the Visual Analogue Scale (EVA), graded from 0 to 10, with zero being the total absence of pain and 10 the maximum level of pain supported by the participant.	Assessed at baseline, 4th week, and 6th week.
Secondary	Perceived Effort Scale (Borg)	The degree of subjective exertion reported by the participants in relation to the lower limbs will be analyzed by Borg's scale of perception of effort of 6 to 20 points, 6 being "very easy" and 20 being "exhaustive."	Assessed at baseline, 4th week, and 6th week.
Secondary	Recovery Perception Scale	The perception of recovery of the lower limb submitted to the eccentric exercise protocol will be evaluated by means of a 10-point Likert Scale, where 1 indicates "not recovered" and 10 "fully recovered".	Assessed at baseline, 4th week, and 6th week.