Exercise Pulmonary Hypertension Clinical Trial
Official title:
Hemodynamic Study of the Pulmonary Circulation in Exercise in Patients With Pulmonary Fibrosis
The study evaluates the rest and exercise hemodynamics of patients presenting either idiopathic fibrotic pulmonary disease or pulmonary fibrosis secondary to connective tissue disease.
Patients with fibrotic pulmonary disease of the above origin will undergo detailed assessment
of functional status with the following examinations: pulmonary function tests,
echocardiogram, 6 minute exercise test, cardiopulmonary exercise test (in the absence of
contra-indications) and finally right heart catheterization. Hemodynamic assessment will take
place at rest and at exercise following the exercise protocol that was recommended by Herve
et al (ERJ 2015) using a cycle ergometer at bedside.
The purposes of the study are:
1. to evaluate the response of the hemodynamic parameters at exercise compared to the
resting parameters in this patient group.
2. to discriminate between precapillary from postcapillary etiology of pulmonary
hypertension.
3. to correlate non-invasive parameters of functional limitation with invasive hemodynamic
parameters.
4. to assess the prognostic role of exercise induced pulmonary hypertension in the specific
patient group.
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