Epilepsy Clinical Trial
Official title:
Combined Role of PET and MEG in Nonlesional Epilepsy in Pediatric Population
The first aim of this study are to evaluate the lobar concordance of FDG-PET and MEG with intracranial electrographic study in children with intractable partial epilepsy. The second aim is to determine if the combined role of FDG-PET and MEG improve detection of epileptogenic zone as defined by invasive intracranial recordings.
Children with poorly controlled epilepsy are extensively investigated with various tools
including MR brain, electroencephalography (EEG), magnetoencephalography (MEG) or position
emission tomography (PET) scans. When MR brain does not show an abnormality, the patient is
said to have nonlesional epilepsy. In these cases, it is even more crucial to be able to
identify the epileptogenic zone, depending on availability of investigative tool.
Recognizing that individual modalities have limitations, the aim of this study is to
determine if combining non-invasive investigations with MEG and PET, which respectively
evaluate the electrical and metabolic activity of the brain, could improve the children with
intractable nonlesional epilepsy with MEG and PET and compared this with invasive
intracranial monitoring. The endpoint of the study being agreement on localizations of
epileptogenic zone using PET and MEG individually and in combination and comparing this with
invasive intracranial monitoring.
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Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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