Endothelial Dysfunction Clinical Trial
Official title:
The Cardiovascular Effects of Nitrogen Dioxide Exposure
Verified date | April 2009 |
Source | University of Edinburgh |
Contact | n/a |
Is FDA regulated | No |
Health authority | Sweden: Regional Ethical Review Board |
Study type | Interventional |
Exposure to air pollution has been linked to increased cardiorespiratory morbidity and mortality. The exact component of air pollution that mediates this effect is unknown, but the link is strongest for fine combustion derived particulate matter derived from traffic sources. It has been demonstrated that inhalation of diesel exhaust impairs vascular vasomotor tone and endogenous fibrinolysis. Recent studies using an inline retrofit particle trap to reduce the particulate component of exhaust have shown that filtering particles leads to a reversal of the endothelial dysfunction seen after diesel exhaust exposure, and have even suggested an augmentation of vascular function. This raises the question of the cardiovascular effects of the gaseous pollutants, the most abundant of which is nitrogen dioxide. In this study we plan to investigate the cardiovascular effects of nitrogen dioxide exposure.
Status | Completed |
Enrollment | 12 |
Est. completion date | December 2008 |
Est. primary completion date | December 2008 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | N/A and older |
Eligibility |
Inclusion Criteria: - Healthy male volunteers Exclusion Criteria: - Current smokers - Significant occupational exposure to air pollution - Regular medication use - Intercurrent illness |
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Basic Science
Country | Name | City | State |
---|---|---|---|
Sweden | Umeå University | Umeå |
Lead Sponsor | Collaborator |
---|---|
University of Edinburgh | Umeå University |
Sweden,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Forearm blood flow measured by venous occlusion plethysmography in response to intraarterial vasodilators (acetylcholine, sodium nitroprusside, bradykinin and verapamil) | 4-6 hours after exposure | No | |
Secondary | Plasma t-PA concentrations after infusion of bradykinin | During forearm study | No | |
Secondary | Exhaled nitric oxide | 4-6 hours after exposure | No |
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