Effect of Amino Acids and Sugar Alcohols on Satiation Peptides and Activation of Specific Brain Regions

Endocrine System Diseases Clinical Trial

Official title:

Effect of Amino Acids and Sugar Alcohols on Release of Satiation Peptides and Activation of Specific Brain Regions in Normal Weight and Obese Subjects

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02823249
• Other study ID #: fMRI Aminoacids
• Status: Completed
• Phase: N/A
• First received: June 27, 2016
• Last updated: February 26, 2017
• Start date: May 2014
• Est. completion date: April 2015

Study information

• Verified date: February 2017
• Source: University Hospital, Basel, Switzerland
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

With this study the investigators investigate the effects of amino acids (tryptophan, leucin) and sugar alcohols (xylitol, erythritol) on satiety mechanisms and brain activation.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 20
• Est. completion date: April 2015
• Est. primary completion date: April 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• Healthy normal weight subjects with a body-mass index of 19.0-24.9

• Healthy obese subjects with a body-mass index of > 30

• Normal eating habits (no diets; no dietary changes; no special dietary habits such as vegetarian/vegan)

• Age 18-40 years

• Stable body weight for at least three months

Exclusion Criteria:

• Smoking

• Substance abuse

• Regular intake of medications (except for oral contraceptives)

• Medical or psychiatric illness

• History of gastrointestinal disorders

• Food allergies

• Pregnancy, breast feeding

• Body piercings that cannot be removed

• History of claustrophobia

• Left-hander

Related Conditions & MeSH terms

• Endocrine System Diseases

Intervention

Dietary Supplement:
• 1.56 g L-Tryptophan

• 1.56 g L-Leucine

• 50 g Xylitol

• 75 g Erythritol

• 75 g Glucose

• Tap water

• Mixed liquid meal (Ensure Plus®; 17% protein, 29% fat and 54% carbohydrate)

Device:
• Nasogastric Tube

Locations

Country	Name	City	State
Switzerland	University Hospital Basel	Basel	Basel-Stadt

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Basel, Switzerland

Country where clinical trial is conducted

Switzerland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Effect of aminoacids on cerebral blood flow measured by functional brain MRI		changes from baseline to one hour after treatment
Primary	Effect of sugar alcohols on cerebral blood flow measured by functional brain MRI		changes from baseline to one hour after treatment
Secondary	Measurement of Plasma Glucose concentrations		changes from baseline to three hours after treatment
Secondary	Measurement of Plasma Insulin concentrations		changes from baseline to three hours after treatment
Secondary	Measurement of Plasma cholecystokinin concentrations		changes from baseline to three hours after treatment
Secondary	Measurement of Plasma Glucagon-like Peptide (GLP-1) concentrations		changes from baseline to three hours after treatment
Secondary	Measurement of Plasma PYY concentrations		changes from baseline to three hours after treatment
Secondary	Measurement of Plasma ghrelin concentrations		changes from baseline to three hours after treatment