Emergencies Clinical Trial
Official title:
International Multicentre Prospective Study on Morphine-induced Adverse Drug Reactions in Emergency Departments: Description and Predictive Factors.
Morphine is the gold standard for treatment of severe acute pain but it has a number of
adverse effects.
No study has so far managed to identify the morphine-induced adverse drug reactions. The
primary objective of this study is to determine predictive factors of morphine-induced
adverse drug reaction when it is used in emergency departments.
We want to study a large cohort of morphine-induced adverse drug reactions patients, the
consequences for patients, mainly in terms of severity, and predictive criteria. This will
allow us to identify some patients most at risk of morphine-induced adverse drug reactions,
and thus to adapt morphine titration and monitoring of these patients. Leading to a better
understanding and a better prediction of adverse effects in patients, it is possible that
part of the "opiophobia" which persists in emergency services disappear. Finally, it is
toward a better security but also a better efficiency in the management of pain patients in
emergencies that leads this study.
The secondary objectives are:
To determine the frequency and severity of adverse events related to morphine. To establish
an inventory of morphine use in emergency departments in the different centres studied.
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