Diffuse Large B Cell Lymphoma Clinical Trial
Official title:
YY-20394 Combined With GEMOX in the Treatment of Patients With Relapsed and/or Refractory Diffuse Large B-cell Lymphoma With a Single Arm, Open, Multicentrized Phase 1b/2 Clinical Trial
This study is a one-arm, open, multicenter phase 1b/2 clinical trial of YY-20394 combined
with GEMOX second-line or above in patients with relapsed and/or refractory diffuse large
B-cell lymphoma.
YY-20394 combined with GEMOX was used as a cycle for 21 days. The dose of YY-20394 was 80mg/
day as recommended in phase 2, and the dose of GEMOX was treated according to clinical
standards.
This study is a one-arm, open, multicenter phase 1b/2 clinical trial of YY-20394 combined
with GEMOX second-line or above in patients with relapsed and/or refractory diffuse large
B-cell lymphoma.
YY-20394 combined with GEMOX was used as a cycle for 21 days. The dose of YY-20394 was 80mg/
day as recommended in phase 2, and the dose of GEMOX was treated according to clinical
standards.
The first six subjects of group to evaluate the safety of YY - 20394 joint GEMOX, if the
joint treatment of 6 cases of subjects before, If YY-20394 and/or chemotherapy related 4
degrees of hematology toxicity or level 3 non hematologic toxicity were appearanced less than
2 cases, continued to dose of 80 mg/day, if more than 2 cases, YY-20394 doses dropped to 60
mg/day.
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