Respiratory Insufficiency Clinical Trial
Official title:
Lung and Diaphragm-Protective Ventilation by Means of Assessing Respiratory Work
This study is designed to test a proposed strategy for lung- and diaphragm-protective ventilation (LDPV) in patients with acute hypoxemic respiratory failure. Ventilation and sedation will be titrated to evaluate whether it is feasible and safe within this patient population.
Lung injury and diaphragm injury incurred by mechanical ventilation have very serious adverse effects on patients with acute respiratory failure. Lung injury results from excessive mechanical stress and strain applied to the lung by the ventilator and/or respiratory muscles, while diaphragm injury results from either insufficient or excessive inspiratory effort. The objective of this study is to investigate a new LDPV strategy designed to prevent both disuse-mediated and load-induced diaphragm injury, while also preventing excess global and regional mechanical stress and strain in the injured lung. To achieve these goals, the following specific targets to be met are: (1) respiratory muscle effort similar to that of healthy subjects breathing at rest, (2) lung stress within safe limits, and (3) clinically acceptable gas exchange. Targets are assessed through measurements of global lung stress, tidal recruitment, inspiratory effort, diaphragm contractile effort and adequacy of respiratory muscle and systemic tissue perfusion. Measurements commence at enrollment and continue for 24 hours consecutively. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05904652 -
High Flow Nasal Oxygen at Extubation for Adults Requiring a Breathing Tube for Treating Severe Breathing Difficulties
|
N/A | |
| Completed |
NCT04030208 -
Evaluating Safety and Efficacy of Umbulizer in Patients Requiring Intermittent Positive Pressure Ventilation
|
N/A | |
| Recruiting |
NCT03697785 -
Weaning Algorithm for Mechanical VEntilation
|
N/A | |
| Recruiting |
NCT02989051 -
Fluid Restriction Keeps Children Dry
|
Phase 2/Phase 3 | |
| Completed |
NCT02930525 -
Effect of High Flow Nasal Cannula vs. Standard Care on Respiratory Stability in Pediatric Procedural Sedation
|
N/A | |
| Recruiting |
NCT02539732 -
Prediction of Outcome of Weaning From Mechanical Ventilation Using the Electrical Activity of the Diaphragm
|
||
| Enrolling by invitation |
NCT02290236 -
Monitored Saturation Post-ICU
|
N/A | |
| Completed |
NCT02056119 -
RCT of Mesh Versus Jet Nebulizers on Clinical Outcomes During Mechanical Ventilation in the Intensive Care Unit
|
N/A | |
| Terminated |
NCT01583088 -
Early Stage Amyotrophic Lateral Sclerosis Phrenic Stimulation
|
Phase 3 | |
| Withdrawn |
NCT00990119 -
High Flow Therapy (HFT) to Treat Respiratory Insufficiency in Chronic Obstructive Pulmonary Disease (COPD)
|
N/A | |
| Completed |
NCT00741949 -
Broncho-alveolar Lavage Under Noninvasive Ventilation With Propofol TCI in Patient With AHRF
|
Phase 3 | |
| Completed |
NCT01411722 -
Electrical Activity of the Diaphragm During the Weaning Period
|
Phase 2 | |
| Recruiting |
NCT00339053 -
Immunonutrition and Thoracoabdominal Aorta Aneurysm Repair
|
Phase 4 | |
| Recruiting |
NCT00187434 -
Comparison of Two Methods of Continuous Positive Airway Pressure (CPAP) to Support Successful Extubation of Infants of Birth Weights ≤ 1500 Grams (C2CPAP)
|
N/A | |
| Completed |
NCT02687802 -
Respiratory Mechanics and Patient-ventilator Asynchrony Index in Patients With Invasive Mechanical Ventilation
|
||
| Not yet recruiting |
NCT05906030 -
Diaphragm Dysfunction and Ultrasound Perioperatively
|
||
| Not yet recruiting |
NCT05508724 -
Recruitment Manoeuvres in Critically Ill Patients
|
||
| Completed |
NCT03850977 -
Is There an Association Between Chronic Pancreatitis and Pulmonary Function
|
||
| Completed |
NCT02845375 -
Effect of Neuromuscular Blockade and Reversal on Breathing
|
Phase 4 | |
| Recruiting |
NCT03309423 -
Is Venous to Arterial Conversion (v-TAC) of Blood Gas Reliable in Critical Ill Patients in the ICU?
|
N/A |