Proteomic Study of Plasma Exosomes in Patients With Diabetic Retinopathy

Status Not yet recruiting

Clinical Trial Summary

Objective: Explore the biomarkers related to proliferative diabetic retinopathy by analyzing the protein expression profile changes of plasma exosomes in patients with difference phases of diabetic retinopathy, and investigate potential molecular mechanisms and therapeutic targets. Methods: Enrich exosomes from plasma by column extraction method. NTA, WB and TEM were used to characterize the obtained exosomes, and exosome proteinomics was performed by chromatography⁃mass spectrometry. Corhorts: The study was divided into four groups: a healthy control group, a diabetic without diabetic retinopathy group, a non-proliferative diabetic retinopathy group, and a proliferative diabetic retinopathy group, with 6 cases in each group.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06188013
Study type	Observational
Source	Xuanwu Hospital, Beijing
Contact	Hang Wu, Master
Phone	+86-13911993866
Email	wuhang2317@163.com
Status	Not yet recruiting
Phase
Start date	January 2, 2024
Completion date	June 30, 2024

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