Diabetic Retinopathy Clinical Trial
The prevalence of diabetes is increasing and the management of the disease is nowadays
considered a major challenge. Affected patients have increased mortality and morbidity as
well as a significant drop in the quality of life. The complications of diabetes can be
classified as microvascular (e.g. nephropathy, neuropathy or retinopathy) or macrovascular
(e.g. cardiovascular or cerebrovascular).
Several large-scale epidemiologic studies indicating that wider retinal venous caliber is
strongly associated with the fasting glucose level as well as with diabetes. Another retinal
vascular abnormality that is associated with diabetes is an abnormal retinal vascular
response to flicker stimulation. Retinal vessel dilatation in response to stimulation with
diffuse flicker light occurs due to a phenomenon called neurovascular coupling. This means
that increased activity of neurons is associated with an increased retinal metabolism. This
leads to a release of endogenous vasodilator substances and increased blood flow. However,
previous studies were limited by the fact that retinal vessel diameters and blood flow were
not measured simultaneously.
The present study aims to investigate whether the response of retinal vessel diameters and
blood flow velocities to flicker stimulation is altered in patients with diabetes. Both
parameters will be measured in real time using Fourier Domain Doppler OCT.
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