Diabetes Mellitus Clinical Trial
Official title:
The Prognostic Value of Lactate is Different Among Septic Patients With or Without Diabetes Mellitus
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Early diagnosis of sepsis and identification of more severe sepsis is important to improve the outcomes .Therefore, reliable markers are required to early identify the high-risk patients. Currently, lactate is widely applied as the marker for evaluating the severity of sepsis and for outcome predicting. DM affects lactate balance and raised baseline lactate. The objective of this study was to compare the different prognostic value of admission lactate for sepsis patients with or without DM.
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host
response to infection. Early diagnosis of sepsis and identification of more severe sepsis is
important to improve the outcomes .Therefore, reliable markers are required to early identify
the high-risk patients.
Currently, lactate is widely applied as the marker for evaluating the severity of sepsis and
for outcome predicting.Nevertheless, the value of lactate for predicting sepsis is still
controversial.The reasons for the different cutoff value may be due to the fact that sepsis
is a heterogeneous disease which has already been defined by a number of clinical, laboratory
and radiologic criteria, rather than specific pathologic findings. Therefore, we hypothesized
that the discrepancy clinical value of lactate may be resulted from the heterogeneous feature
of sepsis.
DM affects lactate balance and raised baseline lactate. The objective of this study was to
compare the different prognostic value of admission lactate for sepsis patients with or
without DM.
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