The Effect of Emotional Working Memory Training on Preventing Depression Occurrence

Depressive Symptoms Clinical Trial

Official title:

A Randomized, Double-blind, Placebo-Controlled Evaluation of the Efficacy of Emotional Working Memory Training in the Prevention Treatment of Depressive Symptoms

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT04346784
• Other study ID #: EMOTION2 2019
• Status: Active, not recruiting
• Phase: N/A
• Start date: December 18, 2019
• Est. completion date: January 10, 2021

Study information

• Verified date: April 2020
• Source: Hunan Normal University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to test whether emotional working memory training and attention bias modification training are an effective neurobehavioral therapy to prevent the occurrence of depression .That is whether emotional working memory training and attention bias modification training are superior to placebo in preventing the occurrence of depression over 1 year after training.

Description:

Attentional bias has been theorized to play a critical role in the onset and maintenance of depression. Attentional bias modification training (ABMT), an experimental paradigm that uses training to induce adaptive attentional bias, was developed to test the causal model and this has therapeutic implications in depression.To test the effect of ABMT on treatment of depressive symptoms, a randomized, double-blind, placebo and blank controlled trial is conducted in college students who are experiencing mild-to-severe symptoms of depression.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 110
• Est. completion date: January 10, 2021
• Est. primary completion date: January 10, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 16 Years to 21 Years

Eligibility

Inclusion Criteria:

• A score of 14 or higher on the Beck Depression Inventory-II.

Exclusion Criteria:

• A current episode of MDD, bipolar disorder, schizophrenia or organic mental disorder;

• Any concurrent psychotherapy;

• Any concurrent psychotropic medication.

Related Conditions & MeSH terms

• Depression
• Depressive Symptoms

Intervention

Behavioral:
• maintaining positive working memory training
Participants complete 10 sessions of maintaining positive working memory training during a two-week period. Each session consists of 15 blocks.
• repressing negative working memory training
Participants complete 10 sessions of repressing negative working memory training during a two-week period. Each session consists of 15 blocks.
• Positive ABMT
Participants complete 8 sessions of attention bias modification training (ABMT) during a two-week period. Each session consists of 218 trials, and the time to complete a training session is 12 minutes.
• Positive placebo ABMT
Participants complete 8 sessions of attention bias modification training (ABMT) during a two-week period. Each session consists of 218 trials, and the time to complete a training session is 12 minutes

Locations

Country	Name	City	State
China	Department of Psychology, Hunan Normal University	Changsha	Hunan

Sponsors (1)

Lead Sponsor	Collaborator
Hunan Normal University

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Changes of depressive symptoms	Depression symptoms tested by clinicians using the Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children (K-SADS)	pre-training, post-training(2 weeks after pre-training), follow-ups(1-week,2-week,4-week,7-week,3-month( booster pre-training), 4-month (booster post-training), 5-month,6-month,12-month after post-training)
Secondary	Changes of self-reported depressive symptoms	Self-reported depressive symptoms assessed by Beck depression scale-second version (BDI-II)	pre-training, post-training(2 weeks after pre-training), follow-ups(1-week,2-week,4-week,7-week,3-month( booster pre-training), 4-month (booster post-training), 5-month,6-month,12-month after post-training)