Crohn Disease Clinical Trial
Official title:
Feasibility of High-impact Exercise to Improve Musculoskeletal Outcomes in Adults With Crohn's Disease
Crohn's disease increases the risk of poor musculoskeletal health, as the inflammatory
disease process directly inhibits regulatory pathways involved in bone and muscle formation
and maintenance. The negative effects of disease on muscle-bone health are compounded by poor
nutritional status, vitamin d deficiency, prolonged exposure to glucocorticoid therapy, and
reduced physical activity. Modern, steroid sparing therapies are successful at inducing
clinical remission in terms of inflammation, however they have limited effect in remedying
observed muscle-bone deficits. Subsequently, patients with Crohn's disease are at increased
lifelong risk of pathological fractures and osteoporosis. Novel adjunctive therapies are
therefore required to complement pharmacological treatments and target muscle-bone deficits,
which are responsible for significant disease burden in Crohn's.
High-impact exercise may be a useful additional therapy for patients with Crohn's disease, as
the mechanical strains produced during this type of exercise, through large magnitude
muscular contractions and ground reaction forces, can promote bone formation and gains in
muscle mass. There have been no previous studies assessing the effects of high impact
exercise in Crohn's disease, so it is unknown if this type of exercise is safe and feasible
in this population. The aim of this study is to assess the feasibility of high-impact
exercise for improving markers of bone and muscle health in adults with Crohn's disease, and
compare the effects of exercise with a group of healthy age and sex matched controls.
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