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Link Between Plasma Citrulline and Lipopolysaccharide Concentrations in the Critically Ill — CITRANS  

Critically Ill Clinical Trial

Official title:
Link Between Plasma Citrulline and Lipopolysaccharide Concentrations in the Critically Ill

Clinical Trial Summary

In critically ill patients, the small bowel permeability is increased, leading to bacterial translocation, and systemic inflammatory response syndrome.

Plasma citrulline is a validated biomarker of functional enterocyte mass. Lipopolysaccharide (LPS) is a part of Gram negative bacteria, and plasma LPS concentration is a biomarker of bacterial translocation. The link between plasma citrulline and LPS in the critically ill is unknown. Investigators hypothesize that patients presenting with low plasma citrulline concentration, with presumed altered small bowel function, would have an increased phenomenon of bacterial translocation, and increased plasma LPS concentration. Investigators aimed to evaluate the link between plasma citrulline and LPS concentrations in critically ill patients at the time of ICU admission.

Clinical Trial Description

n/a

Study Design

Observational Model: Case-Only, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02902276
Study type Observational
Source Centre Hospitalier Universitaire de Besancon
Contact Gaël Piton, MD, PhD
Phone 0033381668224
Email gpiton@chu-besancon.fr
Status Recruiting
Phase N/A
Start date July 2016
Completion date February 2017
View Details
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