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Critical Illness clinical trials

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NCT ID: NCT06462872 Not yet recruiting - Clinical trials for Critically Ill Cirrhotics

To Study the Efficacy of Intravenous Neostigmine in Resolution of Acute GI Paralysis in Critically Ill Cirrhotics

Start date: June 15, 2024
Phase:
Study type: Observational

Aim: To determine the efficacy of intravenous neostigmine in the resolution of acute GI paralysis in patients with Critically Ill Cirrhosis (CIC). Study population: Critically ill cirrhosis patient admitted in liver ICU with new onset acute GI tract paralysis and develop feed intolerance. Study period - 1 years Sample Size • All the consecutive patients admitted in liver ICU during the study time period (Dec 2023 -September 2024) will be screened and those patients meeting with inclusion and exclusion criteria will be enrolled, we intend to enroll 70 patients for the study.

NCT ID: NCT06460363 Not yet recruiting - Delirium Clinical Trials

Transcranial Alternating Current Stimulation on Patients With Delirium and Critical Illness (DeliTACS)

DeliTACS
Start date: September 1, 2024
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to learn if transcranial alternating current stimulation can shorten the duration of delirium in intensive care setting. The main question it aims to answer: - Is it possible to shorten the duration of delirium with transcranial alternating current stimulation? Researchers will compare experimental treatment to sham. Participants will receive experimental or sham treatment on maximum of two days depending on their delirium status. Duration of delirium is recorded and reported as "days alive and free of delirium".

NCT ID: NCT06455696 Recruiting - Critical Illness Clinical Trials

Intra-Hospital Transport of Critically Ill Patients in Intensive Care Unit

TIGRHOU
Start date: January 1, 2024
Phase:
Study type: Observational

Intra-hospital transport is a frequent procedure in the ICU, involving patients with the highest severity scores. Although some studies estimate the rate of adverse events to be around 33% during intra-hospital transport, including 4% of serious adverse events, the epidemiological data available is small, heterogeneous, and probably subject to methodological bias. The aim of this study observational prospective observatoinal study is to determine: - the different practices existing between ICUs ("practice survey") - the occurrence of adverse events during intra-hospital transport provided by intensive care units (epidemiological study)

NCT ID: NCT06453421 Recruiting - Rehabilitation Clinical Trials

Pulmonary Rehabilitation in the Chronically Critically Ill Patient

Start date: February 10, 2023
Phase:
Study type: Observational [Patient Registry]

The goal of this observational study is to learn about the population of chronically critical ill patients who refer to respiratory rehabilitation units. The main questions it aims to answer are: - what are the clinical and pathophysiological characteristics of the population of chronically critical ill patients who refer to respiratory rehabilitation units after hospital admission with the need for prolonged invasive mechanical ventilation via tracheostomy? - what is the response of this patient population to respiratory rehabilitation treatment in terms of functional recovery, weaning from invasive mechanical ventilation, weaning from tracheostomy tube, mortality and return to home? - are there any appreciable indices at admission and/or in the first period of hospitalization which may have a prognostic significance both on short-term objectives (weaning from invasive mechanical ventilation, weaning from the tracheostomy tube) and in the medium-long term (survival, state of health)? Participants will be subjected to a rehabilitation and weaning program consisting of: - physical therapy, - speech therapy, - nutritional assessment and therapy, - in subjects on invasive mechanical ventilation at admission a program of weaning and, if needed, shift from invasive to Non-Invasive Ventilation will be performed.

NCT ID: NCT06447441 Not yet recruiting - Sepsis Clinical Trials

Clinical Outcomes Of Mega-dosage Supplementations Of Cholecalciferol In Critically Ill Patients With Sepsis

MDC-S
Start date: July 1, 2024
Phase: N/A
Study type: Interventional

Non-COVID-19 sepsis (Sepsis) has always been one of the common diseases in critically ill patients. The main treatment strategy is to kill pathogens and mitigate hyperinflammation. One study demonstrated that the supplementation with 576,000 IU cholecalciferol (vitamin D3) as a single dose in critically ill adults in the medical intensive care units (MICUs) can improve clinical outcomes, including acute physiology and chronic health evaluation II score (APACHE II), sequential organ failure assessment score (SOFA), and C-reactive protein (CRP). It is a three-year, multi-center, prospective, parallel, double-blind, randomized controlled clinical trial for 240 eligible subjects, with administrations of vitamin D3 576,000 IU or placebo every 24 hours for 3 days (72 hours) within 96 hours after intensive care unit (ICU) admission.

NCT ID: NCT06440265 Completed - Clinical trials for Intensive Care Unit Acquired Weakness

Validity and Reliability of Korean Version of AM-PAC Inpatient Short Form (Low Function) in Critically Ill Patients

AM-PAC
Start date: March 31, 2023
Phase:
Study type: Observational

The Activity Measure for Post Acute Care (AM-PAC) inpatient short form (low function) evaluates the level of assistance a patient requires another person to provide for distinct functional mobility and daily activities. The objective of the study was to translate and cross-culturally adapt the AM-PAC (low function) into Korean version and assess its reliability and validity . Independent raters assessed 38 patients from ICU using the Korean version of AM-PAC, respectively. Intra-class correlation coefficients (ICCs) and Bland-Altman's plots were used to evaluate reliability, and Cronbach's alpha for internal consistency. Validity was evaluated using Spearman's correlation analysis with other physical function assessment tools (functional status score for the ICU(FSS-ICU), Medical Research Council-sum score(MRC-SS), hand grip strength) and other unrelated factors (body mass index, glucose level).

NCT ID: NCT06438380 Not yet recruiting - Critical Illness Clinical Trials

User Experience of a Telemedicine Platform for the Follow-up of Post Intensive Care Syndrome (PICS)

Start date: May 2024
Phase:
Study type: Observational

Survivors of critical illness may present with a set of physical, emotional and cognitive sequelae, known as Post Intensive Care Syndrome (PICS). These alterations can become chronic over time and significantly affect patients' quality of life. Therefore, follow-up and monitoring of critically ill patients after ICU discharge, for example through telemedicine, could be essential for the prevention, early detection and management of PICS. Our main objective is to evaluate the suitability and user experience of a telemedicine platform from the perspective of critically ill patients. This study proposes the participation of ICU survivors in the design and improvement of a telemedicine platform for PICS follow-up through a qualitative approach. Participants will test the platform in person three months after discharge from the ICU and then undergo a semi-structured interview to assess their experience. The findings derived from this study may contribute to improve both the content and the format of the platform, optimizing resources and facilitating the management of post-ICU sequelae, which will have a positive impact on the patient's recovery process.

NCT ID: NCT06431802 Not yet recruiting - Critical Illness Clinical Trials

Construction and Application of the Visualization Training Platform Based on a Multimodal Standardized Dataset for Pain Assessment in Critically Ill Children

Start date: June 2024
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to learn if the visualization training platform based on a multimodal standardized dataset for pain assessment in critically ill children is applicable for pain assessment training. The main questions it aims to answer are: 1. Does pain assessment training with a visualization training platform based on a multimodal standardized dataset for pain assessment in critically ill children improve participants' knowledge level of pain assessment? 2. Does pain assessment training with a visualization training platform based on a multimodal standardized dataset for pain assessment in critically ill children improve participants' skill level of pain assessment? Researchers will compare a visualization training platform based on a multimodal standardized dataset for pain assessment in critically ill children to on-site lesson to see how well the platform intervention can be applied to pain assessment training. Participants will: 1. Use the visualisation platform or receive on-site lesson for pain assessment training every week for 1 month 2. Test before and 1 month after the start of the study

NCT ID: NCT06431412 Active, not recruiting - Critical Illness Clinical Trials

A Model for Drug Concentration Prediction of Vancomycin

Start date: March 1, 2024
Phase:
Study type: Observational

Objective: This study aims to use machine learning methods to establish an optimal model for predicting serum vancomycin trough concentrations in critically ill patients. Methods: This is a single-center, retrospective study. Data on serum vancomycin concentration in the Critical Care Database of Peking Union Medical College Hospital were screened and extracted to construct a prediction model using machine learning methods. The MIMIC-IV (Medical Information Mart for Intensive Care) database will be further used for external verification of the constructed model. The study has been approved by the Medical Ethics Committee of Peking Union Medical College Hospital (K24C1161).

NCT ID: NCT06425289 Not yet recruiting - Critically Ill Clinical Trials

Macrohemodynamic Impact of Fluid Removal With Net Ultrafiltration in Patients With Continuous Renal Replacement Therapy

Start date: June 1, 2024
Phase:
Study type: Observational

Macrohemodynamic impact of fluid removal with net ultrafiltration in patients with continuous renal replacement therapy. A monocentric ancillary study of the EarlyDry randomized controlled trial.