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NCT ID: NCT06153888 Recruiting - Fluid Overload Clinical Trials

ULtrafiltration-Rate Induced CArdiac Strain (ULRICA) - Study

Start date: March 20, 2023
Phase: N/A
Study type: Interventional

Patients performing chronic hemodialysis (HD) retain more or less water between dialyses. The water is removed by ultrafiltration and usually during the cleansing of waste products - the HD. The length of HD is usually the same as the time of fluid removal while sometimes this may differ. There is no clear guideline. In previous research we noted that the heart releases more NT-pro-BNP during HD in numerous of the patients. The present study aims to clarify if the speed of fluid removal during HD is a factor that may alter the release of cardiac markers during HD. If so the recommendations for the prescription of HD can be updated.

NCT ID: NCT06153303 Recruiting - Chronic Pain Clinical Trials

Internet-based ACT for Endometriosis and Chronic Pain

Start date: January 1, 2024
Phase: N/A
Study type: Interventional

The primary aim of this study is to investigate the effect of Internet-delivered Acceptance and commitment therapy for endometriosis and chronic pain. A pilot study (no randomization; N=10) will be conducted to test the intervention and assessment procedures. The participants will go through an active internet-based ACT treatment focused on education about endometriosis and chronic pain, value-based exposure for avoided situations, and behavior change through exercises targeting the processes mindfulness, cognitive defusion and acceptance. The treatment is delivered on a safe internet platform. Participants have planned telephone contact with their assigned psychologist 2 times during the program and can also contact their psychologist via a message system in the platform and expect answer within 48 hours.

NCT ID: NCT06152471 Recruiting - Diarrhea Clinical Trials

Effect of Salovum™ and SPC-Flakes™ on Abemaciclib-induced Gastrointestinal Toxicity in Early Breast Cancer

Start date: June 7, 2023
Phase: Phase 3
Study type: Interventional

The present study aims to investigate a proactive strategy including Salovum™ and SPC-flakes to prevent the occurrence of abemaciclib-induced diarrhea in patients with early breast cancer.

NCT ID: NCT06152198 Recruiting - Hip Fractures Clinical Trials

Internal Fixation vs Hip Arthroplasty in Older Adults With an Undisplaced Femoral Neck Fracture: A Substudy of the Hipsther Trial

Start date: June 20, 2021
Phase: N/A
Study type: Interventional

Aim To investigate the effect of internal fixation versus hip arthroplasty on physical function and pain in elderly patients. Methods This is a substudy of an on-going nationwide multicenter registry-based RCT named HipSTHeR- (Hip Screws or Total Hip replacement or undisplaced femoral neck fracture in elderly patients) [21]. The aim is to recruit 340 patients with undisplaced or minimally displaced femoral neck fracture, Garden 1 or 2, are randomized to surgery either with internal screw fixation or hip arthroplasty. This substudy aims to investigate the potential differences between internal fixation versus hip arthroplasty regarding physical function and pain 4- and 12- months after surgery. Those included in the main study will be contacted by letter a few weeks after the surgery to be invited to participate in a further study. The assessor will then contact the person by telephone to answer further questions and to obtain informed consent. The follow-ups will be conducted over telephone and mail at 4 and 12 months. During the follow-up the participants will answer questions about their functional level. Information on randomisation and fracture data will be acquired from the Swedish Fracture Register and treatment data from the Swedish Hip Arthroplasty Register. Primary outcome The New Mobility Score will be used as the primary outcome with follow-up at 4- and 12 months. Secondary outcome WOMAC will be used as an additional hip specific patient reported outcome. Activities of daily living will be assessed with Katz ADL index to evaluate the patients' performance and the need of assistance in ADL. Patients' cognitive status will be assessed ALFI-MMSE, adapted from Adult Lifestyles and Function Interview (ALFI-MMSE). The Geriatric Depression Scale (GDS-15), which are developed to identify depressive symptoms. The Philadelphia Geriatric Center Morale Scale (PGCMS) and have been used in several studies including frail people living in residential care facilities and can be used among patients with cognitive impairment.

NCT ID: NCT06151964 Recruiting - Clinical trials for Non-alcoholic Steatohepatitis (NASH)

A Trial to Learn How Safe AZD9550 is in People With Type 2 Diabetes Who Are Overweight or Obese

Start date: September 29, 2023
Phase: Phase 1/Phase 2
Study type: Interventional

AZD9550 is in early development for the treatment of non-alcoholic-steatohepatitis, a type of liver disease that commonly affects overweight and obese patients who have T2DM. The purpose of this study is to investigate the safety, tolerability, and effects of increasing doses of AZD9550 in overweight and obese participants aged 18 through 65 years living with T2DM, and to investigate how AZD9550 is absorbed, distributed, and eliminated from the body.

NCT ID: NCT06149741 Recruiting - Rectal Cancer Clinical Trials

Defunctioning Left-sided Colostomy in Low Anterior Resection for Rectal Cancer

Start date: November 20, 2023
Phase: N/A
Study type: Interventional

This is prospective, multi centre study evaluating a novel type of defunctioning loop stoma after low anterior resection for rectal cancer. Patients will be operated with a complete splenic flexure mobilisation and total mesorectal excision. An anastomosis will be fashioned at the pelvic floor. This will leave a redundant colon which will be brought up and matured in the left iliac fossa. Patient bowel function and quality of life will be monitored at baseline and at one year postoperatively, when the stoma will typically have been reversed. We anticipate less issues with dehydration and kidney injury, associated with the main alternative loop ileostomy. About 20 patients will be included in this pilot study.

NCT ID: NCT06149182 Recruiting - Fibromyalgia Clinical Trials

Does the First Interview Matter: A Randomized Trial Comparing Life Stress Interview Versus a Standard Psychiatric Intake Interview for Patients With Functional Somatic Disorder

Start date: October 9, 2023
Phase: N/A
Study type: Interventional

Functional somatic syndromes (e.g. irritable bowel syndrome, fibromyalgia) and medically unexplained symptoms (e.g. chronic primary pain) are very common in primary care. These patients make 14 times more doctor visits than the general population, but describe themselves as less satisfied with the care they receive. Although Region Stockholm in Sweden recently developed care flows based on 'step up' care for the most common patient groups in primary care, patients with functional or medically unexplained symptoms are not mentioned. Short-term psychodynamic therapies such as Emotional Awareness and Expression Therapy (EAET; Schubiner & Lumley, 2019) and Intensive Short Term Psychodynamic Therapy (ISTDP) have recently been evaluated in three systematic reviews (Abbass et al., 2020, 2021, 2022) and show good results for patients with medically unexplained symptoms. Short-term psychodynamic therapy considers that good treatment outcomes for patients with functional somatic syndromes can be achieved by increasing awareness of emotions and teaching patients to better experience, express and regulate emotions. In several randomized studies, short-term psychodynamic therapy has shown good effects even compared to other treatments, including cognitive behavioral therapy (CBT) (Yarns et al., 2020, Lumley et al., 2017). The purpose of this project is to use a recently developed therapy form, psychodynamic short-term therapy (EAET and ISTDP), in a large-scale randomized controlled trial aimed at patients with medically unexplained symptoms with high health care consumption to clarify effects but also to contribute to information on how care flows in primary care for the patient group can be created. The research question for this specific study is: Can a therapeutic interview (so-called "EAET life-stress interview") focusing on emotional factors in comparison to a psychiatric interview (so-called "basic assessment") contribute to increased interest in psychological treatment and reduction of physical and psychiatric symptoms in patients with medically unexplained symptoms with relatively high health care consumption? Does the order of interview interventions matter?

NCT ID: NCT06148974 Recruiting - Healthy Clinical Trials

Effects of Plant Polar Lipis on Glucose Tolerance

Start date: December 11, 2023
Phase: N/A
Study type: Interventional

In this randomized controlled trial, two different plant polar lipids are investigate with respect to their potential to affect acute and seond meal glucose tolerance and appetite sensations. The effects are compared with a common non-polar commercial oil. The lipids are consumed spread on a white wheat bread. A white wheat bread without added lipids is included as a control product. The test products are consumed at breakfast, and test variables are ivestigated in the postprandial period after the test breakfast and also after a seceond meal standard lunch.

NCT ID: NCT06148779 Recruiting - Osteoarthritis Clinical Trials

Can Digitally Delivered First-line Osteoarthritis Treatment Improve Equal Access to Care

Start date: January 1, 2022
Study type: Observational

To improve chronically ill patients' health and quality of life, long-standing and continuous treatment is needed at an acceptable cost. The purpose of this study was to compare utilization of digital versus face-to-face delivered osteoarthritis (OA) treatment in the 21 different county councils of Sweden that are responsible for providing healthcare to the residents.

NCT ID: NCT06147362 Recruiting - Cancer Clinical Trials

68Ga-NOTA-PEG2-RM26 PET/CT, First in Man Study

Start date: June 1, 2022
Phase: Phase 1
Study type: Interventional

This is an open-label positron emission tomography/computed tomography (PET/CT) study to investigate the diagnostic performance and evaluation efficacy of 68Ga-NOTA-PEG2-RM26 in prostate cancer patients. A single dose of 2 MBq/kg of 68Ga-NOTA-PEG2-RM26 limited to 100-200 MBq per examination will be given intravenously. Visual and semiquantitative method will be used to assess PET/CT images.