There are about 2118 clinical studies being (or have been) conducted in Malaysia. The country of the clinical trial is determined by the location of where the clinical research is being studied. Most studies are often held in multiple locations & countries.
The biggest problem in the orthodontic process is the pain and the long duration of treatment, which is also generally divided into 2 phases, namely the orthodontic tooth movement (OTM) and the retention phase. In recent decades, low-level-laser therapy has gained attention because it is non-invasive, inexpensive, relieves pain and has no significant adverse effects. Low-level-laser therapy (LLLT) has been proved to effectively induce and accelerate the remodeling process of alveolar bone by increasing the number of osteoblasts and osteoclasts. Therefore, LLLT is widely used in OTM to accelerate tooth displacement, but there are few studies and limited evidence on the stability whether it can strengthen and shorten the retention stage to avoid relapse. Thus, the purpose of this study is to investigate the stability after orthodontic treatment by observing the substantial influence of low-level-laser as during retention phase. Research Question(s) 1. Does the low-level laser treatment can enhance stability and shorten retention time after orthodontic treatment or not will be demonstrated through 3 aspects： 1. The Incisor Irregularities Index between laser and control group after application of LLLT at debond (0), 6 and 12 months of retention 2. The interarch dimension: intercanine width, intermolar width, interpremolar width, arch length between laser and control group after application of LLLT at debond (0), 6 and 12 months of retention 3. The overjet and overbite between laser and control group after application of LLLT at debond (0), 6 and 12 months of retention Objective General: The goal of this study is to investigate the stability in retention phase after application of LLLT during leveling and alignment with fixed appliances. Specific: 1. To compare the Incisor Irregularities Index between laser and control group after application of LLLT at debond (0), 6 and 12 months of retention 2. To compare the interarch dimension: intercanine width, intermolar width, interpremolar width, arch length between laser and control group after application of LLLT at debond (0), 6 and 12 months of retention To compare the overjet and overbite between laser and control group after application of LLLT at debond (0), 6 and 12 months of retention
The purpose of the present study is to assess the efficacy of secukinumab 300 mg s.c. (subcutaneous) compared to placebo, each in combination with standard of care, in improving signs, symptoms and physical function in participants with moderate to severe rotator cuff tendinopathy (RCT), using a randomized, double-blind, placebo controlled, parallel group design to minimize bias.
Fractures in and around the hip are common in the elderly and most of them required early surgical fixation. Hip fractures are accompanied with a considerable amount of pain. Based on National Orthopaedic Registry Malaysia (NORM), spinal/neuraxial anaesthesia makes up 66.3%, is the preferred mode of anaesthesia. Severe pain associated with fractured hip often results in difficulty during positioning for neuraxial anaesthesia and hence it is extremely challenging to position the patients in sitting or lateral position for neuraxial anaesthesia procedures. A supra-inguinal fascia iliaca compartment block (S-FICB), a 3 in 1 block involving femoral nerve , lateral femoral cutaneous nerve and obturator nerve. It is famous technique among anaesthesiologist to treat immediate and postoperative pain in hip fractures patients. The pericapsular nerve group (PENG) block is an ultrasound-guided approach, first described by Giron-Arango et al. in 2018 for the blockade of the articular branches of the femoral, obturator and accessory obturator nerves that provide sensory innervation to the anterior hip capsule. It is an alternative regional anaesthesia technique for the management of acute pain after hip fracture. The goal of this clinical trial is to compare the effectiveness of (PENG) block vs (S-FICB) block in reducing positional pain during neuraxial block in patients going for elective internal fixation of neck of femur fractures. And investigators's hypothesis is PENG block is as effective as S-FICB in reducing positional pain during neuraxial block in patients going for elective internal fixation of neck of femur fractures.
This study aims to compare the de-epithelized gingival graft (control group) and modified combined approach for connective tissue graft (test group) in patients undergoing palatal graft harvesting for mucogingival surgery in the oral cavity
This study aims to compare the efficacy of vericiguat versus placebo on change in n-terminal pro-brain natriuretic peptide (NTproBNP) from baseline to Week 16. The primary hypothesis is Vericiguat is superior to placebo in reducing NT-proBNP at Week 16.
This study is conducted to investigate the safety and efficacy of the formulation containing stem cell secretome and licorice root extract in improving vagina laxity (VL) condition of women in Malaysia. This formulation may stimulate cell rejuvenation and trigger cell renewal efficiently as they contained rich mixture of natural, bioavailable polypeptides and plant extracts and these might help improving the VL condition in women. The study duration is 5 weeks and vagina assessment will be carried out at baseline, week 2 and week 5.The main objectives of this study are: 1. To assess the vagina laxity of women in Malaysia after using the formulation. 2. To observe any adverse effect occurrence with the use of the formulation.
This is a randomized, active-controlled, double-blind clinical study designed to evaluate the antiretroviral activity, safety, and tolerability of doravirine/islatravir (DOR/ISL [MK-8591A]) in treatment-naïve participants with human immunodeficiency virus type 1 (HIV-1) infection. It is hypothesized that DOR/ISL is non-inferior to bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) as assessed by the percentage of participants with HIV-1 ribonucleic acid (RNA) <50 copies/mL at Week 48.
The purpose of this study is to evaluate whether milvexian compared to placebo reduce the risk of recurrent ischemic stroke.
The goal of this observational study is to learn about the role of modifiable factors affecting infant circadian rhythm so that recommendations can be made for better health outcomes for the mother and infant. The main questions it aims to answer are: 1. What is the association of prenatal and postnatal maternal circadian clock with infant's circadian clock at 3 months? 2. What is the association of birth outcomes, maternal factors, and environmental factors with infant circadian clock at 3 months? 3. What is the role of infant circadian clock on infant growth and temperament at 6 months of age? Participants will complete a set of questionnaires and provide saliva samples during third trimester of pregnancy and at 3 months after birth of infant.
This is an interventional, prospective, international, multicenter, single-arm, Phase 3, and sequential efficacy and safety study in adolescents and adults with congenital hemophilia A or B with inhibitors to factor VIII (FVIII) or factor IX (FIX) undergoing elective major surgical procedures.