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NCT ID: NCT04115904 Enrolling by invitation - Pain, Postoperative Clinical Trials

Acute Pain Rate of Single Versus Two-visit Root Canal Treatment of Teeth With Necrotic Pulps

Acute pain
Start date: February 8, 2018
Phase: Phase 2
Study type: Interventional

Aim to compare acute pain rate after single-visit ortwo-visits treatment of teeth with necrotic pulp and apical periodontitis .90 teeth with a diagnosis of pulp necrosis and apical radiolucency at the apex.Working length was established with EAL and confirmed radiographically. Flex-R files were used to complete canal preparation. Level ofdiscomfort were recorded and cases with acute postoperative pain.

NCT ID: NCT04065516 Enrolling by invitation - Clinical trials for Gastroesophageal Reflux

ARAT for Reflux Disease After Peroral Endoscopic Myotomy in Patients With Achalasia

ARAT
Start date: July 3, 2019
Phase: N/A
Study type: Interventional

The peroral endoscopic myotomy for the treatment of achalasia is associated with a higher incidence of gastroesophageal reflux disease compared with Heller's myotomy. Remodeling of the esophagogastric junction with hybrid argon plasma could decrease the passage of gastric or gastroduodenal content into the esophagus.

NCT ID: NCT04031508 Enrolling by invitation - Clinical trials for Pulmonary Hypertension of Newborn

Effect of a Parenteral Emulsion With Omega3 on Neonates With PPHN and CDH

CDH-PPHN-N3
Start date: August 12, 2019
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the effect of a parenteral emulsion containing n-3 long-chain polyunsaturated fatty acids (LC-PUFA) in fish oil on clinical outcomes, markers of inflammation and oxidative stress, and pain in neonates with persistent pulmonary hypertension of the newborn (PPHN) compared with those who receive an emulsion containing soy oil and medium-chain triglycerides (MCT) without n-3 LC-PUFA.

NCT ID: NCT03903978 Enrolling by invitation - Clinical trials for Waiting List Control

Efficacy and Effectiveness of a Self-applied Online Program to Promote Resilience and Coping Skills in College Students

Start date: November 1, 2018
Phase: N/A
Study type: Interventional

This study aims to evaluate the effectiveness and efficiency of this intervention protocol applied to three populations of Spanish-speaking university students (Spain, Argentina and Mexico). The purpose of this paper is to present the protocol designed to carry out the randomised controlled study (RCT).

NCT ID: NCT03874702 Enrolling by invitation - Stroke Clinical Trials

Automated Diagnosis of Stroke in Computed Tomography With the Use of Artificial Intelligence

Start date: August 15, 2019
Phase:
Study type: Observational [Patient Registry]

The use of the systems of machine learning for the quantification, location and diagnosis of ischemic stroke in non-contrasted head computed tomography, is a method with high efficacy, accessible and susceptible for standardization, for the assistance in the clinical decision making in the absence of specialized health personnel for the attention of this disease.

NCT ID: NCT03856229 Enrolling by invitation - HIV/AIDS Clinical Trials

Short-term Steroid Therapy in Patients With P. Jirovecii Pneumonia Due to HIV / AIDS

Start date: March 4, 2019
Phase: N/A
Study type: Interventional

The treatment guidelines for Pneumocystis pneumonia (PCP) suggest adding 40mg of prednisone (or its equivalent in methylprednisolone) twice per day on days 1 through 5, 40 mg days 6 through 10, and 20 mg daily on days 11 through 21 in subjects with moderate and serious PCP. Steroids have shown to improve clinical outcome and reduction in mortality in HIV-infected patients the effectiveness of adjuvant steroid treatment for PCP has been observed if it starts within the first 24 to 48 hours. Possibly, there is a long-term benefit with their use in the recovery of function and limitation of chronic pulmonary complications; recently, benefits have been observed in decreasing the incidence of Inflammatory Immune Reconstitution Syndrome (IRIS) due to Mycobacterium tuberculosis. On the other hand, steroids could increase the morbidity related to adverse reactions as well as paradoxical worsening of associated herpes virus infection, which are attributed to IRIS or as a result of immunosuppression generated by their use. Recently, it has been shown that gradually steroids withdrawal is not necessary in patients who have received less than 21 days of treatment. This non-inferiority work aims to confirm the null hypothesis that a reduced steroid scheme in patients with moderate PCP (8 days) and severe pneumonia (14 days) is sufficient to limit long-term ventilatory complications and acute postinflammatory syndrome, compared to the conventional 21-day scheme. It also has been hypothesized that it could be associated with fewer cases of IRIS due to herpes virus type 1,2,3 and 8.

NCT ID: NCT03831984 Enrolling by invitation - Cataract Clinical Trials

Topical Bromfenac for Intraoperative Miosis and Pain Reduction

Start date: March 1, 2018
Phase: Phase 4
Study type: Interventional

To evaluate the effect of bromfenac ophthalmic solution 0.09% for reduction of intraoperative miosis and pain in patient who have undergone femtosecond laser-assisted cataract surgery.

NCT ID: NCT03770754 Enrolling by invitation - Necrosis Clinical Trials

Instrumentation Time Efficiency and Histologically the Debriding Efficacy.

ITE
Start date: January 1, 2019
Phase: N/A
Study type: Interventional

The goal of pulp therapy in the primary dentition is to retain the primary tooth as a fully functional part of the dentition, allowing at the same time for mastication, phonation, swallowing, and the preservation of the space required for the eruption of the permanent tooth. The premature loss of primary teeth may cause changes in the chronology and sequence of eruption of permanent teeth. Maintenance of primary teeth until physiological exfoliation prevents deleterious habits in children. The primary objectives of cleaning and shaping the root canal system are removing soft and hard tissue containing bacteria, providing a path for irrigants to the apical third, supplying space for medicaments and subsequent obturation, retaining the integrity of radicular structure. The choice between pulpotomy and pulpectomy is generally based on the severity of the symptoms clinically and/or radiographically. When indicated, the primary tooth pulpotomy is a relatively simple procedure with generally good clinical results.

NCT ID: NCT03701425 Enrolling by invitation - Clinical trials for Cardiovascular Diseases

Impact of Interventions With a Diet and Exercise on the Cardio-metabolic Status in Multi-risk Population

PANDEMONIO
Start date: June 1, 2017
Phase: N/A
Study type: Interventional

The diseases derived from Metabolic Syndrome caused 75% of the total deaths. It is more profitable to invest in prevention than in the treatment of most cardiovascular diseases. Several institutions consider prevention as one of the main priorities in public health. Patients with Metabolic Syndrome, undergoing Mediterranean diet and exercise program, will have lower fat mass, greater lean mass and muscle strength; in addition to the lower expression of proinflammatory biomarkers, compared to those subjected to standard diet and exercise. OBJECTIVE: To evaluate the changes in body composition and cardiovascular risk in the population with metabolic syndrome undergoing a Mediterranean diet program and / or controlled physical activity. Design: Experimental, longitudinal design, controlled clinical trial, randomized. Population with Metabolic Syndrome in which the effect of Mediterranean diet and / or controlled physical activity will be compared on anthropometric parameters, body composition, cardiometabolic risk and plasma biomarkers.

NCT ID: NCT03683186 Enrolling by invitation - Hypertension Clinical Trials

A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension

Start date: September 23, 2019
Phase: Phase 3
Study type: Interventional

Study ROR-PH-303, ADVANCE EXTENSION, is an open-label extension (OLE) study for participants with WHO Group 1 PAH who have participated in another Phase 2 or Phase 3 study of ralinepag.