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NCT ID: NCT06418087 Recruiting - Clinical trials for Pulmonary Large-cell Neuroendocrine Carcinoma

Durvalumab With Carboplatin and Etoposide Chemotherapy in Pulmonary Large-cell Neuroendocrine Carcinoma (LCNEC)

DUPLE
Start date: May 27, 2022
Phase: Phase 2
Study type: Interventional

A prospective multicenter, single-arm phase II study enrolling treatment-naïve patients with metastatic pulmonary large-cell neuroendocrine carcinoma (LCNEC)

NCT ID: NCT06418048 Recruiting - Clinical trials for Infective Endocarditis

INfectious DIsease REgistry BIObank

INDI-REBIO
Start date: February 1, 2024
Phase:
Study type: Observational [Patient Registry]

Prospective observational study designed to describe the clinical, laboratory, imaging, microbiological characteristics and treatment of specific infectious diseases, with the addition of a dedicated biobank.

NCT ID: NCT06418035 Recruiting - Clinical trials for Autism Spectrum Disorder

Acquisition of Daily Living Skills in Autistic Children: Comparison Between QR Code and a Human Operator

Start date: October 1, 2023
Phase: N/A
Study type: Interventional

Autism spectrum disorder (ASD), is a condition characterized by deficits in social communication and mutual interaction, as well as repetitive and restricted behaviors and interests. This condition manifests itself differently in each individual and can vary greatly in severity and impact on daily life. Autistic children may present various challenges and difficulties in developing daily living skills (DLS). These difficulties may relate to various areas, such as personal autonomy and domestic autonomy. For example, they may have difficulties in acquiring personal hygiene skills, such as dressing and tying their shoes independently. They may have difficulty performing household tasks, such as setting the table, preparing a simple meal, or folding a t-shirt. These difficulties may require specific support and training to help autistic children develop personal autonomy skills and achieve greater independence in different areas of their daily lives. Improving and developing DLS is an important goal in order to improve the quality of life and independence of children with autistic conditions. This protocol aims to acquire new useful DLS within the various settings of daily life. The hypothesis of the present study is the following: video modeling, through the use of the iPad (Qr code scanning), can be more effective in promoting autonomy in children with ASD, compared to a control group that receives a traditional training, without the use of technological instrumentation.

NCT ID: NCT06417528 Recruiting - Post Operative Pain Clinical Trials

Chronic Postsurgical Pain: Multivariate Prediction Model

CPoP
Start date: December 14, 2022
Phase:
Study type: Observational

The goal of this observational study is to identify the risk factors of Chronic Postoperative pain (or Chronic Post Surgery Pain - CPSP) three months after surgery and, subsequently. the development of a risk index to identify high-risk patients considering the multifactorial etiology of CPOP in adult patients undergoing any type of elective surgery.

NCT ID: NCT06416761 Recruiting - Hypertension Clinical Trials

Genetics in the Progression of Nephropathies

Start date: May 19, 2006
Phase:
Study type: Observational

This study evaluates the role of genetic in the development and progression of different nephropaties with particular attention to: - AKI - CKD - Hypertension - ADPKD - CKD-MBD - Patients with decompensated heart failure undergoing either medical or surgery therapy - Patients with hematologic cancer exposed to chemotherapeutic agents or undergoing allogeneic bone marrow transplantation - glomerular diseases

NCT ID: NCT06416215 Recruiting - Obesity Clinical Trials

Promoting Positive Mental Health for Sustainable Eating Behaviors

PROMISE
Start date: January 30, 2024
Phase: N/A
Study type: Interventional

The main aim of the present study is to assess the effects and the effectiveness of a psychological intervention based on the principles of well-being therapy (WBT) in promoting weight-loss, sustainable and healthy eating behaviors and an optimal psychological functioning in patients with obesity.

NCT ID: NCT06415812 Recruiting - Clinical trials for Personality Disorders

Evolutionary Systems Therapy for Personality Pathology

ESTP
Start date: October 2, 2023
Phase: N/A
Study type: Interventional

Evolutionary Systems Therapy is a new form of therapy that has been previously tested in a randomized controlled trial and in a few cases of patients diagnosed with Cluster A personality disorders. The objective of the present study is to investigate the feasibility and preliminary efficacy of Evolutionary Systems Therapy in all forms of personality disorders. The study includes three project actions: (i) a case series on adolescents with personality disorders; (ii) a case series on young adults with personality disorders; (iii) an ecological momentary assessment study to confirm the conceptualization model on all the patients.

NCT ID: NCT06414720 Recruiting - Endometriosis Clinical Trials

Salivary microRNA in Endometriosis: Correlation With Response to Progestin Therapy

ENDOmiRNA
Start date: April 22, 2024
Phase:
Study type: Observational

This study aims to analyze the salivary miRNA specific for patients diagnosed with endometriosis, specifically evaluating the miRNA profile of patients who respond versus those who do not respond to progestin therapy. Ninety patients attending the Chronic Pelvic Pain Clinic will be recruited, and they will be asked to provide a saliva sample before starting medical therapy. The response to the therapy will be evaluated after 4 months from the beginning of the therapy itself.

NCT ID: NCT06414044 Recruiting - Migraine Clinical Trials

Italian Real-life obServational Study on the effecTiveness, sAfety and Tolerability of Atogepant in Migraine Patients

STAR
Start date: May 9, 2024
Phase:
Study type: Observational

The purpose of this prospective and multicentric study is to evaluate the effectiveness and tolerability of atogepant as preventive migraine treatment in a cohort of episodic or chronic migraine patients.

NCT ID: NCT06413823 Recruiting - Clinical trials for Cardiovascular Disease

Prevention and Treatment of Cardiovascular Disease

VPC
Start date: May 9, 2024
Phase:
Study type: Observational

In view of the close interrelationship between the various organs and systems of the body, which cannot be examined in a parceled fashion but rather as an integrated system, this study aims to consider the potential risks associated with cardiovascular disease. By identifying additional, often underestimated, altered functions that may affect the patient's quality of life and interfere with the performance of daily activities, this research study aims to evaluate the patient's functioning in an integrated manner to achieve a holistic view of the health and well-being of the patient and caregiver.