Clinical Trials Logo

Filter by:
NCT ID: NCT05983302 Recruiting - Wounds and Injuries Clinical Trials

Elimination of Odor and Treatment of Malodorous Recalcitrant Wounds by Using Supraz and PRP-FG Versus Standard of Care

Start date: August 20, 2023
Phase: Phase 2/Phase 3
Study type: Interventional

The aim of this study is to eliminate the malodorous of chronic wound and increase the chance of the healing of recalcitrant wounds by using the repairing gel (supraz gel) which has the approved components in wound healing and platelet-rich plasma-fibrin glue.

NCT ID: NCT05979441 Recruiting - Dermatomyositis Clinical Trials

A Study to Assess the Long-term Safety and Efficacy of a Subcutaneous Formulation of Efgartigimod in Adults With Active Idiopathic Inflammatory Myopathy

ALKIVIA+
Start date: September 12, 2023
Phase: Phase 3
Study type: Interventional

The purpose of this study is to measure the long-term safety and tolerability of efgartigimod PH20 SC in adult participants with IIM who previously participated in ARGX-113-2007. Secondary objectives include efficacy measures of efgartigimod PH20 SC in participants with IIM.

NCT ID: NCT05978622 Recruiting - Clinical trials for Diabetic Macular Edema

Observational Study of Adult Participants With Diabetic Macular Edema and Suboptimal Response to Anti-Vascular Endothelial Growth Factor Treated With Dexamethasone Intravitreal Implant

Start date: October 30, 2023
Phase:
Study type: Observational

The dexamethasone 700 μg intravitreal implant (DEX-I) delivers dexamethasone gradually to the retina over time. It is an approved drug for the treatment of DME. This study will assess adult participants with diabetic macular edema (DME) and suboptimal response to anti-vascular endothelial growth factor therapy that are treated with DEX-I in the routine clinical setting. Approximately 327 participants who are prescribed DEX-I by their physicians will be enrolled at approximately 40 sites in approximately 10 countries globally. Participants will be followed for 18 months post-DEX-I implantation according to the routine clinical practice of the prescribing centers. Only one eye per participant will be evaluated in the study. No additional burden for participants in this trial is expected.

NCT ID: NCT05973604 Recruiting - Atrial Fibrillation Clinical Trials

Prevalence of Primary Aldosteronism in Atrial Fibrillation

ERETRIA
Start date: September 1, 2021
Phase:
Study type: Observational

This is an observational prospective cross-sectional study, investigating the prevalence of primary aldosteronism in patients with atrial fibrillation.

NCT ID: NCT05972967 Recruiting - Clinical trials for Paroxysmal Nocturnal Hemoglobinuria

Safety and Efficacy of OMS906 in Paroxysmal Nocturnal Hemoglobinuria Patients With a Sub-optimal Response to Ravulizumab

Start date: March 27, 2023
Phase: Phase 2
Study type: Interventional

The purpose of this study is to assess the safety, tolerability, pharmacokinetics, pharmacodynamics and preliminary efficacy of OMS906 for the treatment of Paroxysmal Nocturnal Hemoglobinuria (PNH) in patients who have a sub-optimal response to ravulizumab.

NCT ID: NCT05964621 Recruiting - Pancreatic Cancer Clinical Trials

Venous Thromboembolism in Primary Pancreatic Tumour Resection

PaTR-VTE
Start date: September 1, 2023
Phase:
Study type: Observational

This study will evaluate the development of venous thromboembolism (VTE) and possible determinants in patients with primary pancreatic cancer undergoing pancreatic cancer resection.

NCT ID: NCT05962801 Recruiting - Periodontitis Clinical Trials

Use of Dual-light Photodynamic Therapy as an Adjunct to Periodontal Treatment in Smokers

Start date: January 23, 2023
Phase: N/A
Study type: Interventional

The goal of this controlled clinical trial is to investigate the impact of regular home use of Lumoral device as an adjunct treatment compared to non-surgical periodontitis treatment (NSPT) alone on biofilm removal and host response in Stage III and Grade C smoking periodontitis patients at 6 months.The main question aims to answer is: • Does regular use of dual-light photodynamic therapy benefit NSPT in Stage III and Grade C smoking periodontitis patients? 30 participants will be asked to use Lumoral device every night before performing oral hygiene for 10 minutes, while the other 30 patients will be asked to perform only oral hygiene. Both of these groups will receive NSPT and will be followed for 6 months from baseline.

NCT ID: NCT05962684 Recruiting - ERAS Clinical Trials

A Greek-designed ERAS Protocol in Elective Craniotomy

ERAS
Start date: May 31, 2023
Phase:
Study type: Observational

The implementation of ERAS protocol in elective cranial neurosurgical cases in a tertiary hospital.

NCT ID: NCT05952557 Recruiting - Clinical trials for Breast Cancer, Early Breast Cancer

An Adjuvant Endocrine-based Therapy Study of Camizestrant (AZD9833) in ER+/HER2- Early Breast Cancer (CAMBRIA-2)

CAMBRIA-2
Start date: October 5, 2023
Phase: Phase 3
Study type: Interventional

This is a Phase III open-label study to assess if camizestrant improves outcomes compared to standard adjuvant endocrine therapy for patients with ER+/HER2- early breast cancer with intermediate-high or high risk for disease recurrence who completed definitive locoregional therapy (with or without chemotherapy). The planned duration of treatment in either arm within the study will be 7 years.

NCT ID: NCT05951296 Recruiting - Clinical trials for Idiopathic Pulmonary Fibrosis

A Study to Investigate Leramistat in Patients With IPF

Start date: August 30, 2023
Phase: Phase 2
Study type: Interventional

To compare the effect of daily oral dosing of leramistat over 12 weeks with placebo in participants aged 40 years or older with idiopathic pulmonary fibrosis (IPF).