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NCT ID: NCT02646267 Enrolling by invitation - Atrial Fibrillation Clinical Trials

The Efficacy and Safety Study of Dabigatran and Warfarin to Non-valvular Atrial Fibrillation Patients

Start date: March 2016
Phase: Phase 4
Study type: Interventional

The purpose of this trial is to demonstrate the efficacy and safety of dabigatran etexilate and different intensity warfarin for the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation.

NCT ID: NCT02641184 Enrolling by invitation - Clinical trials for Coronary Artery Disease

Evaluation of Novel Risk Factors and Clinical Outcomes of Acute Myocardial Infarction

Start date: December 2015
Phase: N/A
Study type: Observational

The aim of this study is to investigate the potential novel risk factors for acute myocardial infarction. Predictors of poor outcomes will be also evaluated.

NCT ID: NCT02602873 Enrolling by invitation - Nephrotic Syndrome Clinical Trials

Study of Tacrolimus Used for Pediatric Patients With Nephrotic Syndrome Based on Pharmacogenomics and Metabonomics

Start date: August 2015
Phase: N/A
Study type: Observational

Tacrolimus is recommended to be the first line therapeutic medication within the several immunosuppressive agents when treating refractory pediatric nephrotic syndrome, because of its definite efficacy and low toxicity. But there are still some key problems which hinder the using of tacrolimus in clinic, such as its narrow therapeutic widow, great individual difference of pharmacokinetics. Routine therapeutic drug monitoring(TDM) is needed in practice. But the disadvantage of TDM is hysteresis, which could lead to treatment failure or toxicity. To find out the reasons of great pharmacokinetic difference between patients and find out the individual proper dosage before administration are important for the clinical using of tacrolimus. It is hot in research of tacrolimus in organ transplant field, such as the association between gene polymorphisms of cytochrome P-450 3A4, 3A5 and multiple drug resistant gene(MDR1) and concentration of tacrolimus. However, there is few study about pharmacogenomics and metabonomics of tacrolimus in patients of nephrotic syndrome. The aim is to study the relationships between pharmacogenomics, metabonomics of tacrolimus and its efficacy, toxicity and blood concentration in patients of nephrotic syndrome, to find out the exact dosage before administration, to provide reference to individual drug administration.

NCT ID: NCT02594449 Enrolling by invitation - Healthy Volunteers Clinical Trials

A Pharmacodynamic and Safety Study of BCS in Healthy Volunteers

Start date: October 2015
Phase: Phase 4
Study type: Interventional

To compare pharmacodynamics among the different concentrations of BCS and NS.

NCT ID: NCT02589106 Enrolling by invitation - Scoliosis Clinical Trials

Anisotropic Textile Braces for Adolescent Idiopathic Scoliosis

Start date: January 2017
Phase: N/A
Study type: Interventional

One of the most common types of 3-dimensional spinal deformities with unknown etiology in youths is adolescent idiopathic scoliosis (AIS). The spinal curvature increases as puberty progresses. Generally, rigid orthotic bracewear is prescribed as non-invasive treatment for moderate AIS if treatment begins early and the orthosis is worn with compliance. Obviously, teenage patients are reluctant to accept a rigid orthosis due to aesthetics and the physical constraint. Therefore, semi-rigid and flexible orthoses have been developed, but their efficacy is still controversial and there are other issues, such as high pain scores. There is clearly room for improvement. Therefore, a garment-type of bracewear will be designed and developed to correct spinal deformity, reduce the possibility of spinal curve progression, and satisfy the needs of the patients as well as take their psychological concerns into consideration.

NCT ID: NCT02562183 Enrolling by invitation - Cerebral Infarction Clinical Trials

The Study to Reevaluate the Safety and Efficacy of Human Urinary Kallikrein

Start date: August 2015
Phase: Phase 4
Study type: Interventional

In order to reevaluate safety and efficacy of human urinary kallikrein in treating acute cerebral infarction ,a multi-center, open label , single group study was designed. Expect to enroll 60 sites and 2186 subjects. Subjects will receive kallikrein treatment according to real clinical practice (suggest above 14days treatment) and 90 days follow up

NCT ID: NCT02548936 Enrolling by invitation - Atherosclerosis Clinical Trials

Efficacy and Safety of Simvastatin-ezetimibe Combination Therapy Among Patients With SLE

Start date: April 2015
Phase: Phase 0
Study type: Interventional

This is a randomized single-blind trial. This study aimed to determine if intensive lipid-lowering therapy (simvastatin-ezetimibe combination therapy) could reduce the progression of atherosclerosis effectively and safely among SLE patients with carotid artery intima thickening. The study results were expected to be helpful for SLE patients in preventing atherosclerosis.

NCT ID: NCT02546297 Enrolling by invitation - COPD Clinical Trials

Comparisons of Inhaled LAMA or LAMA+LABA or ICS+LABA for COPD With Bronchiectasis

Start date: September 15, 2017
Phase: Phase 4
Study type: Interventional

The purpose of this study is to determine which treatment is more effective and safer for the patients in COPD C group with bronchiectasis.The research results will help guide physicians to select appropriate individualized treatment and hopefully provide some evidence-based medicine proofs for revising guide.

NCT ID: NCT02528513 Enrolling by invitation - Delirium Clinical Trials

Midazolam Used Alone or Sequential Use of Midazolam and Propofol/Dexmedetomidine in Mechanically Ventilated Patients

Start date: December 2015
Phase: Phase 4
Study type: Interventional

The purpose of this study was to evaluate effects, safety and cost of midazolam used alone or sequential use of midazolam and propofol/dexmedetomidine for long-term sedation in critically ill, mechanically ventilated patients.

NCT ID: NCT02527811 Enrolling by invitation - Clinical trials for Congenital Heart Diseases

Ulinastatin Injection in in Pediatric Patients Undergoing Open Heart Surgery

Start date: April 2015
Phase: Phase 4
Study type: Interventional

1. Explore the efficacy of Ulinastatin use in improving post-operative pulmonary insufficiency and safety in pediatric patients undergoing scheduled CPB open heart surgery to treat Complex Congenital Heart Disease 2. Explore the efficacy of Ulinastatin use in improving intraoperative hemodynamic instability as well as other post-operative organ recuperation and its impact on hospital stay & cost