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NCT ID: NCT05672966 Not yet recruiting - Clinical trials for Human Papillomavirus Infection

Phase I Clinical Trial of a Candidate HPV Vaccine

Start date: August 1, 2023
Phase: Phase 1
Study type: Interventional

This is a Phase I, first-in-human, randomized, observer-blinded, placebo-controlled, dose escalation study to evaluate the safety, tolerability, and immunogenicity of BV601 (a HPV Vaccine) in healthy adult volunteers.

NCT ID: NCT05652855 Not yet recruiting - Clinical trials for Advanced or Metastatic Solid Tumors

Study of MHB088C in Participants With Advanced or Metastatic Solid Tumors

Start date: January 23, 2023
Phase: Phase 1/Phase 2
Study type: Interventional

This study will evaluate the safety/tolerability, pharmacokinetics and efficacy of MHB088C in participants with advanced or metastatic solid tumors.

NCT ID: NCT05642949 Not yet recruiting - Clinical trials for Advanced Solid Tumor

Study of MHB036C in Participants With Advanced or Metastatic Solid Tumors

Start date: January 23, 2023
Phase: Phase 1/Phase 2
Study type: Interventional

This study will evaluate the safety, pharmacokinetics, and anti-tumor efficacy of MHB036C in participants with advanced or metastatic solid tumors.

NCT ID: NCT05636215 Not yet recruiting - Clinical trials for Locally Advanced Unresectable or Metastatic Solid Tumors

A First-in-human Study of IBI354 in Subjects With Locally Advanced Unresectable or Metastatic Solid Tumors

Start date: January 1, 2023
Phase: Phase 1/Phase 2
Study type: Interventional

This is a Phase 1/2, open-label, multicenter study designed to evaluate the safety, tolerability, and DLTs to establish the maximum tolerated dose (MTD) or maximum administered dose (MAD), and the RP2D of sequential doses of IBI354 (study drug), and to explore and confirm the efficacy, safety and tolerability of IBI354 in subjects with locally advanced unresectable or metastatic solid tumors.

NCT ID: NCT05626959 Not yet recruiting - Clinical trials for Autism Spectrum Disorder

Evaluating the Efficacy of NTI164 in Young People With Autism Spectrum Disorder

Start date: November 30, 2022
Phase: Phase 2/Phase 3
Study type: Interventional

This is an 18 to 54 week study assessing the efficacy of Full-Spectrum Medicinal Cannabis Plant Extract 0.08% THC (NTI164) on the severity of autism spectrum disorder in young people.

NCT ID: NCT05562505 Not yet recruiting - Pneumonia Clinical Trials

Trial of ECMO to De-Sedate, Extubate Early and Mobilise in Hypoxic Respiratory Failure

REDEEM
Start date: November 1, 2022
Phase: N/A
Study type: Interventional

To determine whether a strategy of adding venovenous ECMO to mechanical ventilation, as compared to mechanical ventilation alone, increases the number of intensive care free days at day 60, in patients with moderate to severe acute hypoxic respiratory failure.

NCT ID: NCT05545969 Not yet recruiting - Mucosal Melanoma Clinical Trials

Neoadjuvant Pembrolizumab and Lenvatinib for Mucosal Melanoma

Neo PeLeMM
Start date: March 2024
Phase: Phase 2
Study type: Interventional

In many cancers, early stage diagnosis and early treatment offers the best chance of a prolonged recurrence free- and overall survival. Neoadjuvant immunotherapy involves administering immune checkpoint inhibitors before surgical resection in high-risk resectable disease, such as mucosal melanoma. In resectable cancers, immune checkpoint inhibitors can enhance anti-tumour immunity by exploiting a competent immune system prior to surgery. Activating antigen-specific T cells found in the primary or baseline tumour continue to exert anti-tumour effects on remaining neoplastic cells after the resection of the original tumour, potentially preventing recurrences from occurring. In resectable mucosal melanoma, an opportunity exists to improve clinical outcomes with the addition of neoadjuvant and adjuvant systemic therapy with nivolumab and lenvatinib as an adjunct to surgery.

NCT ID: NCT05509985 Not yet recruiting - Clinical trials for Advanced Solid Tumors

A Phase 1 Study of ASKG315 in Patients With Advanced Solid Tumors

Start date: August 9, 2023
Phase: Phase 1
Study type: Interventional

The study is a Phase 1, open-label, multicenter, dose escalation study to evaluate the safety, tolerability, PK and PD of ASKG315 as a single agent (Part 1) and in combination with pembrolizumab (Part 2) in patients with advanced solid tumors.

NCT ID: NCT05509153 Not yet recruiting - Huntington Disease Clinical Trials

A Randomised Controlled Trial, Of N-Acetyl Cysteine (NAC), for Premanifest Huntingtin Gene Expansion Carriers

NAC-preHD
Start date: November 1, 2022
Phase: Phase 2
Study type: Interventional

NAC-preHD is a phase II randomized placebo controlled study of oral NAC among premanifest HD gene expansion carriers, with clinical and radiological outcome at three years.

NCT ID: NCT05500612 Not yet recruiting - Clinical trials for Glioblastoma Multiforme

MRI Hypoxia Study for Glioblastoma Multiforme (GBM) Radiation Therapy

MANGO
Start date: June 2024
Phase:
Study type: Observational

This study is designed to evaluate the role of Oxygen Enhanced (OE) Magnetic resonance imaging (MRI) and Blood Oxygenation Level Dependent (BOLD) MRI in detecting regions of hypoxic tumour and to evaluate their use as imaging methods to selectively deliver targeted radiotherapy to regions of aggressive disease.