Coronavirus Disease 2019 (COVID-19) Clinical Trial
Official title:
Phase 2, Randomized, Double-Blind, Placebo-Controlled Study of the Effect of Anti-CD14 Treatment in Hospitalized Patients With COVID-19
This study aims to address the following objectives: 1. To determine the efficacy of IC14, an anti-CD14 chimeric monoclonal antibody, in patients hospitalized with respiratory disease and hypoxemia due to SARS-CoV-2, in terms of improving the time to resolution of disease. 2. To determine the efficacy of IC14 in reducing the severity of respiratory disease in patients hospitalized with respiratory disease due to SARS-CoV-2. 3. To determine the safety of IC14 in patients hospitalized with respiratory disease due to SARS-CoV-2.
This is a multicenter, randomized, double-blind, placebo-controlled study of IC14, an antibody to CD14, in reducing the severity of respiratory disease in hospitalized Coronavirus Disease 2019 (COVID-19) patients. Participants will be randomized to IC14 or matching placebo and followed for 60 days after randomization. The study drug will be administered daily on Days 1-4 by intravenous infusion. All participants will receive standard of care antiviral therapy with remdesivir. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04516564 -
A Study of AK119 (Anti-CD73 Antibody), a Treatment for COVID-19, in Healthy Subjects
|
Phase 1 | |
| Not yet recruiting |
NCT04395170 -
Convalescent Plasma (PC) and Human Intravenous Anti-COVID-19 Immunoglobulin (IV Anti COVID-19 IgG) in Patients Hospitalized for COVID-19.
|
Phase 2/Phase 3 | |
| Withdrawn |
NCT04519424 -
CSL324 in COVID-19
|
Phase 2 | |
| Completed |
NCT05437289 -
A Study to Evaluate the Safety and Tolerability of AZD7442 in Healthy Chinese Adults
|
Phase 1 | |
| Completed |
NCT05594147 -
An Observational Study, Called ROCURS, to Learn About COVID-19 Related Outcomes in People With Cancer Who Are Treated With Tyrosine Kinase Inhibitors (TKIs) Including Regorafenib or Sorafenib
|
||
| Withdrawn |
NCT04848467 -
COVID-19: A Trial Studying the SARS-CoV-2 mRNA Vaccine CVnCoV to Learn About the Immune Response, the Safety, and the Degree of Typical Vaccination Reactions When CVnCoV is Given at the Same Time as a Flu Vaccine Compared to When the Vaccines Are Separately Given in Adults 60 Years of Age and Older
|
Phase 3 | |
| Completed |
NCT04588363 -
COVID-19: Pediatric Research Immune Network on SARS-CoV-2 and MIS-C
|
||
| Terminated |
NCT04877743 -
Non-Interventional Enhanced Active Surveillance Study of Adults Vaccinated With AZD1222
|
||
| Completed |
NCT04742725 -
A Study to Evaluate the Efficacy and Safety of Prothione™ Capsules for Mild to Moderate Coronavirus Disease 2019 (COVID-19)
|
Phase 2 | |
| Completed |
NCT04375761 -
COVID-19: Human Epidemiology and Response to SARS-CoV-2
|
||
| Completed |
NCT04545047 -
Observational Study of Convalescent Plasma for Treatment of Veterans With COVID-19
|
||
| Completed |
NCT04378777 -
Immunophenotyping Assessment in a COVID-19 Cohort
|
||
| Completed |
NCT04327206 -
BCG Vaccination to Protect Healthcare Workers Against COVID-19
|
Phase 3 | |
| Terminated |
NCT05375760 -
A Randomized, Open-label, Dose-ranging Study in Adults and Pediatric Individuals ≥ 12 Years of Age to Assess the Safety, Immunogenicity, Pharmacokinetics, and Pharmacodynamics of AZD7442, for Pre-exposure Prophylaxis of COVID-19
|
Phase 2 | |
| Completed |
NCT04344977 -
Collection of Anti-SARS-CoV-2 Immune Plasma
|
||
| Terminated |
NCT04389840 -
Dociparstat for the Treatment of Severe COVID-19 in Adults at High Risk of Respiratory Failure
|
Phase 2/Phase 3 | |
| Withdrawn |
NCT04425733 -
MK-5475 in Participants With Hypoxemia Due to COVID-19 Pneumonia (MK-5475-009)
|
Phase 1 | |
| Not yet recruiting |
NCT04438837 -
Hydroxychloroquine Post-Exposure Prophylaxis for Coronavirus Disease (COVID-19) Among Health-Care Workers
|
N/A | |
| Completed |
NCT04409509 -
Treatment With CSL312 in Adults With Coronavirus Disease 2019 (COVID-19)
|
Phase 2 | |
| Completed |
NCT04275245 -
Clinical Study of Anti-CD147 Humanized Meplazumab for Injection to Treat With 2019-nCoV Pneumonia
|
Phase 1/Phase 2 |