The Role of Nebulized Budesonide in the Treatment of Acute Exacerbations of COPD

COPD Acute Exacerbation Clinical Trial

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT00274222
• Other study ID #: 2006-3
• Status: Terminated
• Phase: N/A
• First received: January 9, 2006
• Last updated: January 9, 2006
• Start date: January 2003
• Est. completion date: October 2005

Study information

• Verified date: January 2006
• Source: Inonu University
• Contact: n/a
• Is FDA regulated: No
• Health authority: TURKEY: INONU UNIVERSITY PULMONARY MEDICINE
• Study type: Observational

Clinical Trial Summary

This study was designed to evaluate the hypothesis that nebulized budesonide) might be an alternative to systemic corticosteroids (SC) in the treatment of patients with acute exacerbations of COPD (AECOPD).

Description:

Patients, hospitalized with AECOPD, were randomized into three groups. Group I received only bronchodilator treatment (BDT), Group II received SC (40 mg prednisolon) plus BDT, and Group III received nebulized budesonide (NB)(1500 mcg qid) plus BDT. Improvement rates in multiple parameters during 10-day hospitalization, and acute exacerbation and re-hospitalization rates within one-month after discharge were compared between the groups.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 120
• Est. completion date: October 2005
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• COPD patients who were admitted to our pulmonary department for an acute exacerbation were prospectively enrolled in the study

Exclusion Criteria:

• COPD patients hospitalized with specific reasons like pneumonia, pulmonary emboli, congestive heart failure, pneumothorax etc. as the cause of acute exacerbation, or patients with risk of imminent respiratory failure requiring mechanical ventilation or direct admission to the ICU were excluded.

Study Design

N/A

Related Conditions & MeSH terms

• COPD Acute Exacerbation

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Inonu University