Anesthesia, TIVA, Balanced Anesthesia, NK Cell

Colorectal Cancer Clinical Trial

Official title:

The Differences Between the Effects of Total Intravenous Anesthesia (TIVA) and Balanced Anesthesia on NK Cell and Cytokine Response in Colorectal Cancer Patients Undergoing Cytoreductive Surgery and HIPEC(Hyperthermic Intraperitoneal Chemotherapy)

Clinical Trial Details — Status: Withdrawn

Administrative data

• NCT number: NCT05951842
• Other study ID #: 3-2017-0378
• Status: Withdrawn
• Phase: N/A
• Start date: April 16, 2018
• Est. completion date: February 28, 2020

Study information

• Verified date: July 2023
• Source: Gangnam Severance Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Anesthetic method was reported to have an impact on postoperative long-term outcome in cancer patients. In this study, we will investigate the effect of different anesthetic methods on NK cell activity, cytokine response and postoperative outcome in colorectal cancer patients undergoing CRS and HIPEC. We will compare propofol-based total intravenous anesthesia (TIVA) with balanced anesthesia to determine the effect of propofol, inhalation agent, and opioid on tumor genesis, recurrence, NK cell activity, cytokine response, and postoperative outcome.

Recruitment information / eligibility

• Status: Withdrawn
• Enrollment: 0
• Est. completion date: February 28, 2020
• Est. primary completion date: February 28, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years to 70 Years

Eligibility

Inclusion Criteria:

1. Colorectal cancer patients undergoing elective cytoreductive surgery and HIPEC (20-70 yrs old)

2. American Society of Anesthesiologists physical status I, II, III

Exclusion Criteria:

1. Patients under 20 years old.

2. Patients with long-term steroid therapy or immunosuppressive therapy.

3. Patients with long-term NSAIDs therapy.

4. Patients who cannot communicate with other person or with cognitive disorder.

5. Patients who cannot read the consent form.

Related Conditions & MeSH terms

• Colorectal Cancer
• Colorectal Neoplasms

Intervention

Drug:
• anesthetic method
Patients will be assigned to one of the groups, TIVA group or Balanced anesthesia group. In TIVA group, anesthesia will be maintained by propofol and remifentanil infusion under target controlled infusion. In contrast, anesthesia will be maintained by sevoflurane and remifentanil infusion in the balanced anesthesia group.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Gangnam Severance Hospital

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Postoperative immune function (NK cell count)	Postoperative immune function will be measured at baseline, POD#1, and POD#7. Postoperative immune function will be investigated by measuring NK cell count.	Postoperative day 1