Castaneda D, Popov VB, Verheyen E, Wander P, Gross SA New technologies improve adenoma detection rate, adenoma miss rate, and polyp detection rate: a systematic review and meta-analysis. Gastrointest Endosc. 2018 Aug;88(2):209-222.e11. doi: 10.1016/j.gie.2018.03.022. Epub 2018 Apr 1. Review.
Corley DA, Levin TR, Doubeni CA Adenoma detection rate and risk of colorectal cancer and death. N Engl J Med. 2014 Jun 26;370(26):2541. doi: 10.1056/NEJMc1405329.
Faul F, Erdfelder E, Lang AG, Buchner A G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007 May;39(2):175-91.
Lebwohl B, Kastrinos F, Glick M, Rosenbaum AJ, Wang T, Neugut AI The impact of suboptimal bowel preparation on adenoma miss rates and the factors associated with early repeat colonoscopy. Gastrointest Endosc. 2011 Jun;73(6):1207-14. doi: 10.1016/j.gie.2011.01.051. Epub 2011 Apr 8.
Siegel RL, Miller KD, Jemal A Cancer statistics, 2019. CA Cancer J Clin. 2019 Jan;69(1):7-34. doi: 10.3322/caac.21551. Epub 2019 Jan 8.
Sonnenberg A, Amorosi SL, Lacey MJ, Lieberman DA Patterns of endoscopy in the United States: analysis of data from the Centers for Medicare and Medicaid Services and the National Endoscopic Database. Gastrointest Endosc. 2008 Mar;67(3):489-96. doi: 10.1016/j.gie.2007.08.041. Epub 2008 Jan 7.
Sulz MC, Kröger A, Prakash M, Manser CN, Heinrich H, Misselwitz B Meta-Analysis of the Effect of Bowel Preparation on Adenoma Detection: Early Adenomas Affected Stronger than Advanced Adenomas. PLoS One. 2016 Jun 3;11(6):e0154149. doi: 10.1371/journal.pone.0154149. eCollection 2016.
Szura M, Bucki K, Matyja A, Kulig J Evaluation of magnetic scope navigation in screening endoscopic examination of colorectal cancer. Surg Endosc. 2012 Mar;26(3):632-8. doi: 10.1007/s00464-011-1930-8. Epub 2011 Sep 30.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
