Colonoscopy Clinical Trial
Official title:
Intravenous Fluid Administration in Patients Undergoing Colonoscopy: Double Blind, Randomised Clinical Trial of Underlying Acid-base Derangement
The purpose of this study is to determine whether fluid administration in patients undergoing colonoscopy should affect acid-base disorder in term of the strong ion differences.
This is a prospective, double-blinded, randomized control trial. The study enrolls 90
consecutive outpatients, well-prepared bowel, scheduled to undergo routine colonoscopy for
screening, surveillance, or diagnosis of colorectal diseases. At the outpatient clinic, the
co-researcher invites patients who meet the inclusion criteria to join the study. The
process of the project is explained to the interested patients in details before an informed
consent is obtained and the first blood sample is conducted.
On the day of colonoscopy, all participants are randomized equally into three groups: Normal
saline solution (NSS, n = 30) as control group, lactated Ringer's solution (LRS, n = 30) and
acetated Ringer's solution (ARS, n = 30) as treatment groups. The second blood sample is
obtained from patients via 20-gauge needle in either forearm immediately before an allocated
intravenous (IV) fluid administered on the same site. The volume of fluid is calculated by
means of Holliday and Segar formula.
The colonoscopy under total intravenous anesthesia is performed between 9:00 a.m. and 3:00
p.m. At the end of colonoscopy, the patients spontaneously wake up in the recovery room.
After they gain conscious and all vital signs are stable; the intravenous fluid is off and
the third blood sample is taken in the other forearm. After completion of the procedure, the
patient is advised to follow the discharge instructions.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Treatment
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