Effects of Docosahexaenoic Acid (DHA)-Rich Fish Oil on Cerebral Haemodynamics

Cognitive Function Clinical Trial

Official title:

The Cognitive And Cerebral Hemodynamic Effects Of DHA-Rich Fish Oil: A Dose-Ranging Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01075932
• Other study ID #: 16N2
• Status: Completed
• Phase: N/A
• First received: February 24, 2010
• Last updated: February 24, 2010
• Start date: April 2009
• Est. completion date: August 2009

Study information

• Verified date: February 2010
• Source: Northumbria University
• Contact: n/a
• Is FDA regulated: No
• Health authority: United Kingdom: Research Ethics Committee
• Study type: Interventional

Clinical Trial Summary

DHA has previously been shown to increase regional cerebral blood flow response to tactile stimulation in aged monkeys; modulation of cerebral blood flow in humans has yet to be demonstrated. Given that the brain relies on a constant supply of blood-borne metabolic substrates (e.g. glucose, oxygen), increasing regional cerebral blood flow may also have an impact on cognitive function. The current study aims to investigate the effects of two doses of DHA-rich fish oil on task-related cerebral hemodynamic response and cognitive performance in healthy adults.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 65
• Est. completion date: August 2009
• Est. primary completion date: May 2009
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 35 Years

Eligibility

Inclusion Criteria:

• Male/Female

• 18-35 years

• Healthy

• No herbal supplements/prescription medications (excl. contraceptive pill)

• Non smoker

• Native English speaker

Exclusion Criteria:

• consumes oily fish

• takes omega-3 supplement

• food allergies to treatment ingredients

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Cerebral Blood Flow
• Cognitive Function

Intervention

Dietary Supplement:
• DHA-rich fish oil
Either 1 g or 2 g DHA-rich fish oil taken daily for 12 weeks. Participants in the 1 g group will also consume 1 g olive oil placebo capsules per day to maintain double blind.
• Placebo
2 g placebo (olive oil) taken daily for 12 weeks

Locations

Country	Name	City	State
United Kingdom	Northumbria University	Newcastle upon Tyne	Tyne and Wear

Sponsors (2)

Lead Sponsor	Collaborator
Northumbria University	Ginsana SA

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Cerebral blood flow	Cerebral blood flow will be assessed using Near Infrared Spectroscopy while participants complete a series of cognitive tasks.	12 weeks	No
Secondary	Cognitive function	Cognitive function will be assessed using a series of tasks that evaluate working memory, attention and executive function.	12 weeks	No

External Links

•   Brain, Performance and Nutrition Research Centre, Northumbria University