Cognitive Function Clinical Trial
Official title:
Cerebral Blood Flow, Cerebro-electrical Activity and Behavioural Effects of Epigallocatechin Gallate (EGCG) Administration in Healthy, Young Adults
Epigallocatechin gallate (EGCG) is the most abundant catechin (sometimes referred to as tea
flavonoids) in green tea extract. A review by Nagle et al (2006) identifies that a large
amount of research indicates EGCG (amongst other catechins) is responsible for most of the
potential health benefits associated with green tea. EGCG is brain permeable (Nakagawa &
Miyazawa, 1997), and it is considered to have neuroprotective and neurorescue effects
including modulation of cell survival and cell cycle genes (Levites et al 2002).
Although there have been several human studies looking at the bioavailability of EGCG when
administered in varying doses, there have been no studies that have specifically
investigated the cognitive effects of this catechin in humans. Therefore, the purpose of
this study is to assess the cerebral blood flow (using Near Infrared Spectroscopy),
cerebro-electrical activity (EEG) and behavioural effects of EGCG. A randomised,
double-blind, placebo-controlled, balanced crossover study will assess the effects of 135 mg
and 270 mg pure EGCG in 24 healthy, young adults (18-35). Prior to the first active study
day participants will attend a screening/training visit where relevant exclusion criteria
will be assessed including any food sensitivities. They will also complete a caffeine
consumption questionnaire in order to control for potential caffeine withdrawal effects as a
result of restrictions of the study.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Basic Science
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