Delirium Clinical Trial
Official title:
Biomarkers in Cerebrospinal Fluid in Critical Care Patients With Delirium
Critical care patients are at a high risk of developing delirium and impaired cognitive
function 3 and 12 months after their ICU stay. In this study the aim is to try to elucidate
the pathophysiology behind delirium in the ICU and subsequent development of cognitive
dysfunction in ICU survivors.
Biomarkers in cerebrospinal fluid (CSF) will be analysed in patients with and without
delirium in the ICU. Samples will also be taken 3 and 12 months after the ICU-stay. CSF will
also be obtained in healthy age- and sexmatched controls undergoing surgery.
Critical care patients are at a high risk of developing delirium, a form of acute brain
dysfunction, and may develop impaired cognitive function 3 and 12 months following their ICU
stay.
In this study the aim is to try to elucidate the pathophysiology behind delirium in the ICU
comparing patients with and without delirium and possible development of cognitive
dysfunction in ICU survivors. Neuroinflammatory markers and markers of structural damage in
cerebrospinal fluid (CSF) will be analysed in patients with and without delirium assessed
with the CAM-ICU (Confusion Assessment Method) test in the ICU. CSF samples will also be
taken in ICU-survivors, 3 and 12 months after the ICU-stay. For comparison CSF will be
obtained in healthy age- and sexmatched controls undergoing surgery in spinal anesthesia.
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