Cognitive Change Clinical Trial
Official title:
The Impact of Acute Trans-resveratrol Administration on Whole Body Metabolism During Cognitive Task Performance: a Double Blind, Randomised, Placebo-controlled Investigation.
Background: Increased cerebral vaso-dilation during cognitive demand is hypothesised to
improve cognitive performance due to an improved micronutrient status. Despite previous
research demonstrating that oral resveratrol can modulate cerebral haemodynamics, this has
not translated into expected improvements to cognitive performance in young, healthy
populations. As the brain is the most metabolic organ in the body, even subtle changes to
fuel utilization and overall energy expenditure are detectable during cognitive demand. The
measurement of both overall energy expenditure and fuel utilization may provide further
insight to the effects of resveratrol and whether oral supplementation of this polyphenol can
provide clear, cognitive benefits in a young, healthy sample.
Objectives: The current study investigated the metabolic consequences of resveratrol on whole
body metabolism and fuel oxidisation during cognitive performance.
Methods: This repeated measures, double blind, placebo controlled, balanced design required
participants (N=24 for metabolic activity & N=26 for cognitive outcomes) to complete a serial
subtraction demand battery at baseline, 45 minutes, 2 and 3 hours following 500 mg, 250 mg
trans-resveratrol or inert placebo, on three separate occasions whilst connected to an
on-line gas analysis system.
n/a
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