A Pilot Study of Candesartan as a Treatment for Cocaine Dependence

Status Terminated

Clinical Trial Summary

The purpose of this study is to see if a drug called Candesartan will help to reduce use of cocaine.

Clinical Trial Description

The noradrenergic system may play an important role in cocaine addiction in humans. Angiotensin II (Ang II) is known to enhance noradrenergic activity, which contributes to effects on blood pressure and sympathetic nervous system responses to stress. Inhibition of Ang II has been shown to reduce cravings for stimulants, including cocaine and methamphetamine.

This clinical trial among 75 cocaine-dependent subjects is designed to test the efficacy of the Angiotensin II receptor antagonist, Candesartan, for treatment of cocaine dependence. The results of this study will provide medical safety and efficacy data, and will guide future pharmacotherapy trials using this class of medications for cocaine addiction.

This 8-week trial includes a 1-week titration of the medication and 7-weeks of full dose medication (weeks 2-8), with all subjects receiving the active agent.

At the conclusion of the trial, subjects who wish to be referred to an appropriate treatment program or treatment research program will be assisted with a referral. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01938664
Study type	Interventional
Source	Baylor College of Medicine
Contact
Status	Terminated
Phase	Phase 2
Start date	January 2013
Completion date	July 2016

View Details

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