Porous Metronidazole Loaded Matrix for Local Treatment of Periodontitis.

Status Active, not recruiting

Clinical Trial Summary

Aim of the study is the efficiency assessment of porous Metronidazole loaded matrix based on gelatin/hydroxyethylcellulose blend in treatment of deep periodontal pockets resulting from severe chronic periodontitis. The matrix was invented and produced in Department of Drug Form Technology, Wroclaw Medical University.

The porous metronidazole (MTZ) loaded matrix was fabricated by the freeze-drying technique. The morphology, mechanical properties, in vitro degradation, MTZ release from dried sponge were evaluated and also the clinical trials were performed.

Patients suffering from chronic periodontitis are examined. To evaluate oral hygiene API (Approximal Plaque Index) and the gum inflammation BOP (Bleeding on Probing) and PBI (Papilla Bleeding Index) indices are used. The clinical examination is performed 3 times. On the first visit the output indicators are defined. The subgingival scaling is performed and Metronidazol on porous matrix is applied to the selected periodontal pockets. 2 control tests of periodontal indices are carried out after one week and one month from the application.

In the control group after scaling/root planing procedure, there is no application of metronidazole.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03791099
Study type	Interventional
Source	Wroclaw Medical University
Contact
Status	Active, not recruiting
Phase	Phase 4
Start date	April 23, 2018
Completion date	April 2019

View Details

See also
Status	Clinical Trial	Phase
Not yet recruiting	`NCT06400069` - Role of NLRP6 in Chronic Periodontitis
Completed	`NCT05231096` - Comparison of the Effect of Gingival Massage of Aloe-vera Gel and Sidr Honey on Chronic Periodontitis	N/A
Completed	`NCT03203746` - Gingival Crevicular Fluid Levels of Protein Carbonyl Following the Use of Lycopene in Chronic Periodontitis	Phase 1/Phase 2
Active, not recruiting	`NCT03354338` - Amoxicillin to Prevent Bacteria and Inflammatory Biomarkers After Intensive Periodontal Therapy	Phase 2
Completed	`NCT02516111` - Comparison of Autologous PRF, 1% Alendronate and 1.2% Atorvastatin Gel in Chronic Periodontitis Treatment	Phase 2/Phase 3
Completed	`NCT02174146` - Leptin and Visfatin in Diabetic Patients With Periodontitis Before and After Periodontal Therapy	N/A
Terminated	`NCT02568163` - Influence of Stress on Non Surgical Periodontal Treatment	N/A
Completed	`NCT02430519` - Benefits of Platelet Rich Fibrin In Mandibular Molar Furcation Defects	N/A
Completed	`NCT01438333` - Efficacy of INERSAN in Patients With Chronic Periodontitis as Adjunctive to Full Mouth Disinfection	N/A
Completed	`NCT01233765` - Analysis of Neutrophil Response in Chronic Periodontitis	N/A
Completed	`NCT02218515` - Treatment of Intrabony Periodontal Defects With Enamel Matrix Derivatives and Autogenous Bone Graft	Phase 4
Completed	`NCT02197260` - Antimicrobial Therapy as Adjunct to Periodontal Treatment: Effect of Timing	Phase 4
Not yet recruiting	`NCT03270280` - Comparison of Salivary Interleukin-1β and Matrix Metalloproteinase-8 Levels in Individuals With Chronic Periodontitis	Phase 2
Not yet recruiting	`NCT04026828` - Evaluation of Possible Genes in Periodontal Diseases by Genetic Methods
Completed	`NCT04643288` - Nanocrystalline Hydroxyapatite Bone Substitute for Treating Periodontal Intrabony Defects	N/A
Completed	`NCT04697199` - The Adjunctive Effect of Probiotics to Non Surgical Treatment of Chronic Periodontitis	Phase 1
Completed	`NCT03039244` - Evaluation of Antimicrobial Photodynamic Therapy as an Adjunct to Periodontal Treatment in Smokers	N/A
Completed	`NCT02898675` - Advantages of Autologous Platelet-Rich Fibrin Membrane on Growth Factor Levels and Periodontal Healing	N/A
Completed	`NCT02518152` - Platelet Rich Fibrin+1% Alendronate in Treatment of Chronic Periodontitis	Phase 2/Phase 3
Completed	`NCT02851823` - Combined Use of Er:YAG and Nd:YAG Laser	N/A