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NCT00433264 Clinical Trial

The Interrelation of the Vasculature, Endothelium, Bone Metabolism and Uremic Toxins in Peritoneal Dialysis

Chronic Kidney Disease Clinical Trial

— INVEST-PD  

Official title:
The Interrelation of the Vasculature, Endothelium, Bone Metabolism and Uremic Toxins in Peritoneal Dialysis

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00433264
Other study ID # ML3645
Secondary ID
Status Completed
Phase Phase 0
First received February 7, 2007
Last updated March 4, 2009
Start date February 2007
Est. completion date December 2008

Study information
Verified date March 2009
Source Universitaire Ziekenhuizen Leuven
Contact n/a
Is FDA regulated No
Health authority Belgium: Institutional Review Board
Study type Observational

Clinical Trial Summary

Despite major advances in the treatment of chronic kidney disease, the age and sex matched mortality far exceeds that of the normal population. As in the normal population, the majority of deaths are related to cardiovascular disease. Mounting data point to the lethal synergy between chronic kidney disease and cardiovascular disease. This relation is present from early stages of chronic kidney disease on.

Several uremic toxins have been demonstrated to play an important role in kidney disease related endothelial dysfunction. In peritoneal dialysis patients, data on the relation between uremic toxins, endothelial dysfunction and microparticles are lacking.

The investigators hypothesize that endothelial dysfunction and uremic toxins are interrelated in peritoneal dialysis patients

Recruitment information / eligibility
Status Completed
Enrollment 62
Est. completion date December 2008
Est. primary completion date December 2008
Accepts healthy volunteers No
Gender Both
Age group 18 Years and older
Eligibility Inclusion Criteria:

- age > 18

- Maintenance peritoneal dialysis

Exclusion Criteria:

- No informed consent

- Peritonitis

Study Design

Observational Model: Case-Only, Time Perspective: Prospective

Related Conditions & MeSH terms

Intervention

Procedure:
• peritoneal dialysis
individualised

Locations
Country Name City State
Belgium Universitaire Ziekenhuizen Leuven Leuven Vlaams-Brabant

Sponsors (1)
Lead Sponsor Collaborator
Universitaire Ziekenhuizen Leuven

Country where clinical trial is conducted

Belgium, 

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