Chronic Heart Failure Clinical Trial
Official title:
The TOSCA Registry: Epidemiology, Clinical and Prognostic Value of Hormonal and Metabolic Deficiencies in Chronic Heart Failure
The objective of this study is to determine whether the presence of metabolic alteration and anabolic deficiencies in patients with chronic heart failure are able to identify a subset of patients with poor outcome.
Despite the effectiveness of the neurohormonal model to explain the progression of heart
failure and the many insights that it provided for the development of new therapies, there is
increasing clinical evidence that suggests that our current models fail to completely explain
the disease progression. Thus, neurohormonal models may be necessary but not sufficient to
explain all aspects of disease progression in the failing heart. There is evidence suggesting
that in heart failure there is a metabolic imbalance characterized by the predominance of the
catabolic status over the anabolic drive.
Aim of this registry is to determine the prevalence of hormone/metabolic deficiencies in
heart failure patients and to look for possible association with clinical variables.
Moreover, enrolled patients will be followed up for a mean of 2,5 years in order to collect
outcome data including all-cause mortality, cardiovascular mortality, hospitalizations.
This is a multi-center observational study involving several Italian Department of
Cardiology, Endocrinology, Internal Medicine
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