Postoperative Dexamethasone on Post-Cesarean Pain

Cesarean Section Complications Clinical Trial

Official title: Postoperative Dexamethasone on Post-Cesarean Pain in Patients Using Medication Assisted Treatment (MAT)

Status Recruiting

Clinical Trial Summary

Investigating if giving post-operative dexamethasone to patients with a history of opioid use disorder on medication assisted treatment during pregnancy improves their pain scores and decreases their opioid use after cesarean section.

Clinical Trial Description

For this study, the researchers are most interested in an option that would be able to be administered consistently (same time/same way): that labor nurses could give and without requiring the patient to have had an epidural placement. Further, Gabapentin, clonidine and ketamine are associated with CNS effects like sedation or confusion that could make health care providers less likely to be comfortable giving these women additional oxycodone due to possible worsened sedation or respiratory depression. Lastly, the researchers wanted to give a drug that both obstetricians and pediatricians were comfortable with from extensive use in our maternal population. Thus, a single administration IV dexamethasone was chosen for this study. Dexamethasone has been used as an adjunct for post-operative pain management in many types of surgeries. Although no large randomized trials exist, several small trials suggest an analgesic and opioid sparing effect of dexamethasone post-operatively for both pregnant and non-pregnanat patients; however these studies excluded patients on MAT ;

Related Conditions & MeSH terms

• Cesarean Section Complications
• Post-Cesarean Pain

• NCT number: NCT04067609
• Study type: Interventional
• Source: Yale University
• Contact: Victoria Wesevich, MD
• Phone: 475-298-6149
• Email: victoria.wesevich@yale.edu
• Status: Recruiting
• Phase: Phase 4
• Start date: July 20, 2020
• Completion date: November 30, 2024