Cerebral Oxygenation and Blood Flow in Tobacco Use Disorder Clinical Trial
Official title:
Investigation of Oxygenation and Blood Flow in the Brain of Smokers and Their Relation to Smoking Abstinence.
Cerebral oxygenation and blood flow in tobacco use disorder and their relation to smoking abstinence will be measured with MRI" ändern in "Cerebral oxygenation and blood flow in tobacco use disorder
In this study, cerebral oxygenation and tobacco-related attentional bias in smokers and
non-smokers will be measured with magnetic resonance imaging (MRI).
In this study, the oxygen extraction fraction (OEF), the cerebral blood flow (CBF) and the
cerebral metabolic rate of oxygen (CMRO2) are to be measured in smokers and non-smokers using
MRI. On the one hand, the influence of chronic smoking (i.e. smokers versus non-smokers) and
on the other hand the effect of acute nicotine administration (in smokers) on these
parameters will be examined. Furthermore, the influence of these parameters on fMRI results
is to be investigated using the example of a stimulus-reaction task. It can be assumed that
the OEF does not change through nicotine administration, but differs in smokers and
non-smokers and is associated with the strength of tobacco addiction in smokers. CBF and
CMRO2 are expected to be reduced in abstinent smokers, but can be normalized by nicotine
administration. In this study, 20 smokers and 10 never-smokers will be investigated.
Never-smokers will be examined once with MRI and questionnaires, whereas smokers will be
examined twice: before and after a smoking break.
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