Clinical Trial Details
— Status: Completed
Administrative data
| NCT number |
NCT04945915 |
| Other study ID # |
05-2018-139 |
| Secondary ID |
|
| Status |
Completed |
| Phase |
|
| First received |
|
| Last updated |
|
| Start date |
August 6, 2018 |
| Est. completion date |
March 30, 2020 |
Study information
| Verified date |
October 2023 |
| Source |
Pusan National University Yangsan Hospital |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Observational
|
Clinical Trial Summary
DAMPs (damage associated molecular patterns) are endogenous molecules that are expressed by
cell stress or cell damage and play an important role in tissue (or host) defense and repair
by activating the innate immune system. This is not the case with infections or injuries.
Briefly, it starts when the immune system is activated by a receptor that recognizes a damage
pattern, and it is a generic term for continuous responses by endogenous molecules expressed
in this process. Recently, immuno-cancer drugs for cancer treatment by applying this immune
response are also emerging. In cardiac surgery using cardiopulmonary bypass (CPB), there are
more deleterious effects and adverse effects caused by using CPB than the surgery itself.
There are several studies that have revealed the association between DAMPs and the degree of
complications by approaching them from the point of view of tissue damage caused by the use
of CPB. Therefore, we intend to investigate the changes in DMAPs over time during, and after
cardiac surgery and the differences in DAMPs according to the presence or absence of
postoperative pulmonary complications.
Description:
DAMPs (damage-associated molecular patterns) are endogenous molecules expressed as a result
of cell stress or damage. They play a crucial role in tissue or host defense and repair by
activating the innate immune system. This differs from cases of infections or injuries. In a
nutshell, the process begins when the immune system is triggered by a receptor that
recognizes a damage pattern. DAMPs is a broad term encompassing continuous responses by
endogenous molecules expressed during this process. More recently, there has been a growing
focus on using this immune response for cancer treatment through immuno-cancer drugs. In
cardiac surgery using cardiopulmonary bypass (CPB), various types of damage occur, including
intravascular cannulation, exposure to the surface of the bypass circuit,
ischemia-reperfusion injury, and surgical injury (operative trauma). During this process, the
expression of pro-inflammatory cytokines and DAMPs (damage-associated molecular patterns)
takes place. This leads to a response similar to sterile systemic inflammatory response
syndrome (SIRS). As a result of this process, patients become more vulnerable to post-surgery
infections or remote organ failure due to immune suppression.
Several studies have explored the link between DAMPs and the extent of complications by
assessing tissue damage resulting from CPB usage. However, there is no study on the
relationship between the occurrence of pulmonary complications and DAMPs in cardiac surgery,
and therefore the authors aimed to determine changes in DMAPs over time during, and after
cardiac surgery and the differences in DAMPs according to the presence or absence of
postoperative pulmonary complications.
