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Evaluation of Non-opioid Balanced General Anesthesia in Cardiac Surgery With Extracorporeal Circulation: a Randomized, Controlled, Multicenter Superiority Trial — OFACAR  

Cardiac Surgery Clinical Trial

Official title:
Evaluation of Non-opioid Balanced General Anesthesia in Cardiac Surgery With Extracorporeal Circulation: a Randomized, Controlled, Multicenter Superiority Trial

Clinical Trial Summary

Opioid-free anesthesia (OFA) is a general anesthesia based on the use of hypnotics and non-opioid analgesics (lidocaine, ketamine, dexamethasone, esmolol). This technique has been used for the past 10 years, during which randomized and non-randomized studies have demonstrated a number of positive effects on cardiac function: - better analgesia and decreased postoperative morphine consumption, - better respiratory function, - better hemodynamic stability, - better postoperative cognitive function. The hypothesis of the present study is that the use of OFA during cardiac surgery is associated with: - Improved intraoperative hemodynamic stability - A decrease in the incidence of postoperative complications - A reduction in intensive care and hospital length of stay

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04886453
Study type Interventional
Source Centre Hospitalier Universitaire Dijon
Contact
Status Completed
Phase Phase 3
Start date August 30, 2021
Completion date March 21, 2024
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