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Clinical Trial Summary

This study will test the use of focused ultrasound ablation, low-dose gemcitabine (a chemotherapy) and the combination of focused ultrasound ablation plus low-dose gemcitabine in patients with early-stage breast cancers. We will be testing the effects of each of these regimens on cells in the immune system. We hypothesize that the combination of focused ultrasound ablation and gemcitabine will decrease myeloid-derived suppressor cells and will increase T cell activity. We also hypothesize that focused ultrasound ablation and low-dose gemcitabine will be safe and will result in non-inferior surgical completion rates and tumor margin assessments.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04796220
Study type Interventional
Source University of Virginia
Contact Olena Glushakova, MS
Phone 434-409-6206
Email oyg2n@hscmail.mcc.virginia.edu
Status Recruiting
Phase Phase 1
Start date January 27, 2022
Completion date January 2025

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