Brain Tumor Clinical Trial
Official title:
Multimodality Statistical Model of Early Response of High Grade Glioma to Radiation Therapy
RATIONALE: Diagnostic procedures, such as magnetic resonance imaging, may help doctors predict a patient's response to treatment and help plan the best treatment. PURPOSE: This clinical trial is studying magnetic resonance imaging in response to radiation therapy in patients with high grade glioma.
Detailed DescriptionOBJECTIVES:
I. To develop a multimodality statistical model to act as a surrogate marker scheme of early
changes in high grade glioma patients undergoing radiation therapy, using conventional MRI,
MR diffusion tensor imaging, perfusion, permeability, and spectroscopic imaging while
incorporating the radiation dose calculations delivered locally and the results of a
clinical questionnaire into the model.
II. To assess treatment response to tumor and normal tissue changes. OUTLINE: Patients
undergo multimodality MRI imaging at baseline, weeks 1, 2, 3, 5, and 6, and then 4-6 weeks
after completion of radiation therapy.
;
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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