Brain and Central Nervous System Tumors Clinical Trial
Official title:
Phase II Study of Hydroxyurea for the Treatment of Recurrent and/or Nonoperable Meningioma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of hydroxyurea in treating patients who have recurrent and/or unresectable meningioma.
OBJECTIVES: - Determine complete, partial, or stable response to hydroxyurea in patients with recurrent and/or nonresectable meningioma. - Determine response at 2 years to this regimen in these patients. - Determine overall and disease free survival of these patients after this regimen. - Determine quality of life of these patients. - Determine the toxicities of this regimen in these patients. OUTLINE: This is a multicenter study. Patients are stratified according to grade of disease (I vs II or III). Patients receive oral hydroxyurea daily for 2 years. Quality of life is assessed before treatment, then every 3 months for 2 years. PROJECTED ACCRUAL: A total of 60 patients (30 per stratum) will be accrued for this study. ;
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