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Mechanism of Action of Electroconvulsive Therapy — MoA-ECT  

Bipolar Depression Clinical Trial

Official title:
Mechanism of Action of Electroconvulsive Therapy

Clinical Trial Summary

This is an observational neuroimaging study assessing the effects of ECT on the brains of patients with unipolar and bipolar depression.

Clinical Trial Description

This project aims to use functional connectivity magnetic resonance imaging (fcMRI) to study patients with unipolar and bipolar depression receiving ECT. Patients will be scanned before and after a full course of ECT and clinical measures for depression severity and memory will be obtained at the same times.The project has the following aims and hypothesis: (1) to determine the therapeutic antidepressant mechanism of action of ECT at the circuit level (2) to determine the mechanism of action of iatrogenic amnesia caused by ECT at the circuit level (3) to study the use of fcMRI as a state biomarker for depression (4) to study the use of fcMRI as a predictor of response for depression. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04059952
Study type Observational
Source Massachusetts General Hospital
Contact DNN Inbox
Phone 617-724-8780
Email mghdnn@mgh.harvard.edu
Status Recruiting
Phase
Start date June 28, 2019
Completion date December 1, 2024
View Details
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