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Clinical Trial Summary

This study is being conducted to support the clinical development of acalabrutinib in patients who are unable to swallow capsule and require nasogastric (NG) tube placement.


Clinical Trial Description

This is an open-label, single-center, randomized, 3-period, crossover study of acalabrutinib suspension administered via NG tube in healthy subjects to evaluate the relative bioavailability and proton-pump inhibitor (rabeprazole) effect.

The study is divided in 3 periods.

Period 1 of the study is designed to investigate the effect of proton-pump inhibitor on the pharmacokinetics (PK) of acalabrutinib suspension. Period 2 and 3 of the study are designed to investigate the bioavailability of acalabrutinib suspension relative to an oral capsule formulation. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04435483
Study type Interventional
Source AstraZeneca
Contact
Status Completed
Phase Phase 1
Start date May 22, 2020
Completion date June 26, 2020

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