Atrial Fibrillation Clinical Trial
Official title:
Angiotensin II-Antagonist in Paroxysmal Atrial Fibrillation Trial (ANTIPAF Trial)
Hypothesis:
Blocking the angiotensin (AT) II type 1 receptor (Olmesartan) reduces the incidence of
episodes of atrial fibrillation in patients with paroxysmal atrial fibrillation during 12
months by more than 25% compared to standard medication without angiotensin II type 1
receptor.
A total of 422 subjects will be included in the two study groups. The treatment arm will
receive 40mg Olmesartan per day, the remaining patients will receive placebo. Follow-up is 12
months. Daily Tele-ECG recordings will determine the cardiac rhythm and asymptomatic episodes
of atrial fibrillation (AF) every day. Concomitant therapy with AV-nodal blocking drugs are
allowed during the study. In case of severe AF-induced symptoms, an antiarrhythmic "recovery
medication" (amiodarone) is allowed during follow-up.
Double-blind, central randomization, two treatment groups, stratified by beta-blocker use. 211 patients in each treatment arm. ;
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