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Clinical Trial Summary

Surfactant replacement therapy (SRT) improves oxygenation and survival in NRDS and some infant ARDS. SRT was tried in adult ARDS with conflicting results. Research by Filoche and Grotberg helped to understand the failure of previous clinical trials and yielded a strong scientific rationale for SRT success, now allowing to design a new administration protocol for SRT in adults, to be tested by this clinical trial in COVID-19 adult ARDS patients. Patients will be randomized to receive either a bronchial fibroscopy alone (with aspiration of secretions) or a bronchial fibroscopy with administration of 3 mL/kg of a solution of poractant alpha diluted to 16 mg/mL and distributed into each of the 5 lobar bronchi.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04384731
Study type Interventional
Source Versailles Hospital
Contact Sandrine ROUX
Phone +33139239777
Email sroux@ch-versailles.fr
Status Recruiting
Phase Phase 2
Start date May 29, 2020
Completion date July 31, 2021

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