Aplastic Anemia Clinical Trial
OBJECTIVES: I. Evaluate the efficacy of related, HLA-identical bone marrow transplantation
following cyclophosphamide (CTX) and antithymocyte globulin in patients with aplastic
anemia.
II. Evaluate the efficacy of related, HLA-nonidentical bone marrow transplantation following
CTX and total-body irradiation/total-lymphoid irradiation in patients with aplastic anemia.
PROTOCOL OUTLINE: Patients with HLA-identical donors receive cyclophosphamide/mesna,
antithymocyte globulin (ATG), and methylprednisolone (MePRDL), followed by allogeneic marrow
transplantation.
Patients with HLA-nonidentical (5/6 or 4/6) donors and those with a systemic reaction to ATG
receive the same dosage of myeloablative chemotherapy and rescue. In addition, these
patients are treated with total-body irradiation, total-lymphoid irradiation, and
methotrexate.
All patients received MePRDL and cyclosporine for graft-versus-host prophylaxis.
;
Endpoint Classification: Efficacy Study, Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
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A Phase II Dose-escalation Study Characterizing the PK of Eltrombopag in Pediatric Patients With Previously Untreated or Relapsed Severe Aplastic Anemia or Recurrent Aplastic Anemia
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Phase 2 | |
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Phase 2 | |
| Completed |
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|
N/A | |
| Completed |
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NMA Haplo or MUD BMT for Newly Diagnosed Severe Aplastic Anemia
|
Phase 2 | |
| Not yet recruiting |
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Study of MRI Monitoring in Patients With Aplastic Anemia and Low or Int-1 Risk of MDS Complicated With Iron Overload
|
N/A | |
| Recruiting |
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Comparison of Two Different Doses of Rabbit ATG-Fresenius With Cyclosporin in the Treatment of Acquired Aplastic Anaemia
|
N/A | |
| Completed |
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Phase III Randomized Study of Cyclophosphamide With or Without Antithymocyte Globulin Before Bone Marrow Transplantation in Patients With Aplastic Anemia
|
Phase 3 | |
| Recruiting |
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Reduced-Intensity Conditioning for the Prevention of Treatment-Related Mortality in Patients Who Undergo a Hematopoietic Stem Cell Transplant
|
Phase 2 | |
| Completed |
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Ibrutinib for the Treatment of COVID-19 in Patients Requiring Hospitalization
|
Phase 1 | |
| Not yet recruiting |
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CsA+ATG+AVA vs. CsA+AVA for the Treatment of Newly-diagnosed SAA in the Elderly
|
Phase 4 | |
| Completed |
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Phase IIA Open Label Study to Evaluate Efficacy and Safety of BL-8040 Followed by (hATG), Cyclosporine and Methyprednisolone in Adult Subjects With Aplastic Anemia or Hypoplastic Myelodysplastic Syndrome
|
Phase 2 | |
| Completed |
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Nonmyeloablative Allogeneic Transplant
|
N/A | |
| Completed |
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Non-Myeloablative Allogeneic Stem Cell Transplantation With Matched Unrelated Donors for Treatment of Hematologic Malignancies, Renal Cell Carcinoma, and Aplastic Anemia
|
N/A | |
| Completed |
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Stem Cell Factor Medication for Aplastic Anemia
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Phase 1 | |
| Recruiting |
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Phase 2 | |
| Not yet recruiting |
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Efficacy and Safety of Hetrombopag in Non-severe Aplastic Anemia
|
Phase 2/Phase 3 | |
| Completed |
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Phase 2 | |
| Recruiting |
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|
Phase 1/Phase 2 | |
| Recruiting |
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Bone Marrow and Kidney Transplant for Patients With Chronic Kidney Disease and Blood Disorders
|
N/A | |
| Terminated |
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Pooled Unrelated Donor Umbilical Cord Blood Transplant For Hematologic Malignancy Needing Allogeneic Stem Cell Transplant Without Related HLA-Match
|
Phase 2 |