Defining the Neural Dynamics of Concept Retrieval Using Electrocorticography

Aphasia Clinical Trial

Official title:

Defining the Neural Dynamics of Concept Retrieval Using Electrocorticography

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04620928
• Other study ID #: PRO00038561
• Status: Completed
• Phase: N/A
• Start date: August 2, 2021
• Est. completion date: January 31, 2023

Study information

• Verified date: January 2023
• Source: Medical College of Wisconsin
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study will look at the way activity within the brain changes over time while a person is trying to think about certain everyday concepts. To measure brain activity accurately, we will be using electrodes placed on people's brains during awake brain surgery.

Description:

This study will measure the dynamics of cortical activity among early modal cortex and multimodal cortical regions during conceptual retrieval using electrocorticography. Participants will be patients undergoing awake temporal lobe craniotomies. During the surgery patients will have multiple high-density grids placed to simultaneously record activity in multiple areas while the patient is performing language tasks. Activity in each of these regions will be tested for timing differences and informational directionality to determine the temporal dynamics.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 4
• Est. completion date: January 31, 2023
• Est. primary completion date: January 31, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Clinically determined to require an awake left temporal resection of a brain lesion with concurrent language testing.

• English as a first language.

Exclusion Criteria:

• Significant preoperative neuropsychological deficits in memory or naming.

• Patients with inability to make decisions regarding their participation in this research project.

• Surgeon does not plan to expose the area of interest or determines that recording during the resection will interfere with his surgical plan.

Related Conditions & MeSH terms

• Aphasia

Intervention

Behavioral:
• Concepts
Images and sounds that are characteristic of various common objects.

Locations

Country	Name	City	State
United States	Medical College of Wisconsin	Milwaukee	Wisconsin

Sponsors (1)

Lead Sponsor	Collaborator
Medical College of Wisconsin

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Brain activity	Electrocorticographic brain activity measured from brain surface	Recorded immediately during experiment