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NCT02630212 Clinical Trial

The Relationship Between ALDH2 and Aortic Dissection

Aortic Dissection Clinical Trial

— RALAD  

Official title:
The Relationship Between ALDH2 and Aortic Dissection

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT02630212
Other study ID # 2015QLMS37
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date December 2015
Est. completion date December 2019

Study information
Verified date December 2018
Source Qilu Hospital of Shandong University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The purpose of this study is to evaluate the impact of ALDH2 Glu504Lys polymorphism on aortic dissection.

Recruitment information / eligibility
Status Recruiting
Enrollment 400
Est. completion date December 2019
Est. primary completion date December 2019
Accepts healthy volunteers No
Gender All
Age group N/A and older
Eligibility Inclusion Criteria:

- Chinese Han people diagnosed with aortic dissection in Qilu Hospital

Exclusion Criteria:

- Aortic dissection based on trauma, connective tissue diseases and pregnancy

- Patients with tumor

- Patients with no written consensus

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
China Qilu Hospital of Shandong University Jinan Shandong

Sponsors (1)
Lead Sponsor Collaborator
Qilu Hospital of Shandong University

Country where clinical trial is conducted

China, 

Outcome
Type Measure Description Time frame Safety issue
Primary Number of patients with different ALDH2 genotype DNA was extracted from venous blood;genomic DNA underwent PCR amplification; finally, PCR products were purified and directly sequenced by Invitrogen Corp or Biosune Corp.Then ALDH2 genotype was distinguished depend on a G-to-A missense mutation on exon 12 of ALDH2 gene. 1-30 days after samples collected
Secondary Concentration of inflammatory factors in blood and aortic specimen Concentration of 4-HNE?MMP-2?MMP-9 detected by elisa kit?IHC or western blot in relevant specimen. 1-30 days after samples collected
Secondary ALDH2 activity Activity of ALDH2 was detected in blood and aortic specimen depend on its reducibility of NAD+ 1-30 days after samples collected
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