Anterior STEMI Clinical Trial
Official title:
Ceramide Level as Apredictor of Outcomes in Patients of Anterior Myocardial Infarction Undergoing Primary Coronary Intervention
Ceramide level as a predictor of outcomes in patients of anterior myocardial infarction undergoing primary Coronary intervention
Ceramides are a family of lipid molecules that are found in high concentrations within cell
membranes and play a key role in a variety of physiological functions including apoptosis,
cell growth, cell adhesion and plasma membrane integrity maintenance.(1)
All tissues can synthesize ceramides de novo from saturated fats and sphingosine.(2) the (
LDL ) Present in atherosclerotic plaque is rich in ceramide and contain 10 - 50 fold higher
content of ceramide when compared with plasma LDL .(3)
Ceramide (d18:1/16:0) is associated with the fraction of necrotic core tissue and lipid core
burden in coronary atherosclerosis.(4) Previous clinical research found that circulating
ceramides are elevated in patients with hypertension,(5) obesity (6 - 7) and type II diabetes
mellitus.
Previous clinical research found that elevated ceramide plasma concentrations are associated
with coronary plaque vulnerability evaluated by intravascular ultrasound .
virtual Recent studies showed targeted profiling of ceramides predicted short-term and
long-term major adverse cardiac events.
Plasma ceramide level is also positively associated with the levels of total cholesterol. [8
- 9] The plasma ceramides that have been studied as high-risk factors are Cer (d18:1/16:0),
Cer (d18:1/18:0) and Cer (d18:1/24:1) and the ratios of these ceramides to Cer (d18:1/24:0)
[10 - 11].
However, it is tempting to speculate that ceramides are associated with plaque vulnerability
as they are known to fuel many central atherosclerosis processes including lipoprotein
aggregation and uptake, inflammation, superoxide anion production, andapoptosis 12 - 13 - 14
;